摘要
阻塞性睡眠呼吸暂停综合征(OSAS)以慢性间歇低氧为基础,通过多种发病机制导致心血管疾病(CVD)的发生。OSAS合并CVD已经成为威胁人类健康的重大疾病,引起了社会的广泛关注。既往研究主要集中在两者的病理生理机制上,而对血清学预测指标的研究较少。血脂指标简便易测、反应灵敏;脂肪因子指标可能是新的治疗靶点;蛋白质指标对调节糖脂代谢、早期诊断高血压以及心肌缺血起重要作用,本文将从上述3个方面进行重点阐述,以期为临床提供新的诊疗思路。
Obstructive sleep apnea syndrome(OSAS) is basically characterized by chronic intermittent hypoxia and leads to cardiovascular disease(CVD) through a variety of pathogeneses. OSAS with comorbid CVD has become a major disease threatening human health, arousing widespread concern in society. Previous studies mainly focused on the pathophysiological mechanisms of the two with few on serological predictors. Blood lipid is a sensitive index requiring simple and easy measurement;fat factor may serve as a new therapeutic target;protein indicators play an important role in glucose regulation and lipid metabolism, early diagnosis of hypertension and myocardial ischemia. Focusing on the above three aspects, this article aims to provide new insights into clinical diagnosis and treatment.
作者
李英英
高晓玲
LI Ying-Ying;GAO Xiao-Ling(Department of Respiration and Critical Care,Second Hospital of Shanxi Medical University,Taiyuan 030001,China)
出处
《中华老年多器官疾病杂志》
2022年第11期854-857,共4页
Chinese Journal of Multiple Organ Diseases in the Elderly
基金
国家自然科学基金面上项目(81870076)。
