摘要
A族β溶血性链球菌(GAS)是儿童常见感染病原,其引起的扁桃体炎性反应反复发作,即为复发性A族链球菌性扁桃体炎(GAS-RT)。新近研究认为,GAS-RT并非传统意义上的感染性疾病,而是一种免疫敏感性疾病,经由超抗原(SAgs)和生发中心(GC)的滤泡辅助T细胞(Tfh)相互作用,发挥对GC的B细胞细胞毒作用来逃避免疫应答,该理论为临床提供了新的免疫靶向治疗的思路。
Group A beta-hemolytic Streptococcus(GAS)is a common infectious agent in children which may cause recurrent inflammation of the tonsils,known as recurrent group A Streptococcus tonsillitis(GAS-RT).Recent studies found that GAS-RT is not an infectious disease as traditional sense,but rather than an immunosensitive disease that evades the immune response through the interaction between superantigens(SAgs)and follicular helper T cells(Tfh)in the germinal center(GC),which exerts a cytotoxic effects on B cells in the GC.This theory suggested a potential new strategy for clinical treatement.
作者
施佳
蔡成
SHI Jia;CAI Cheng(Department of Neonatology,Shanghai Children's Hospital,Shanghai Jiaotong University,Shanghai 200062,China)
出处
《基础医学与临床》
2023年第2期336-340,共5页
Basic and Clinical Medicine
关键词
复发性扁桃体炎
免疫机制
链球菌热原外毒素A
T滤泡辅助细胞
细菌疗法
recurrent tonsillitis
immune mechanism
Streptococcus pyrogenic exotoxins A
T follicular helper cells
bacteriotherapy
