摘要
肥胖引起的2型糖尿病是我们目前面临的最严重的非传染性疾病之一,脂肪组织中的慢性炎症是导致肥胖人群患2型糖尿病的关键。本文首先从细胞水平和分子水平综述了由炎症介导的肥胖与2型糖尿病关系的研究进展,聚焦免疫细胞和信号通路,其次总结了以免疫细胞与信号通路为靶点的膳食干预治疗研究成果,包括调整巨噬细胞极化状态、T细胞功能以及信号通路活性,以期寻求安全、健康、高效的降血糖膳食原料和有关的特殊医学用途配方食品原料,从而为2型糖尿病的膳食干预疗法提供思路和方案。
Type 2 diabetes mellitus arising from obesity is one of the most serious noncommunicable diseases which currently have serious impacts on human health.Chronic inflammation in adipose tissue is the key to developing type 2 diabetes mellitus in obese people.This paper firstly reviews the progress in the relationship between obesity mediated by inflammation and type 2 diabetes mellitus from the cellular and molecular levels,focusing on immune cells and signaling pathways.Secondly,it summarizes the results of dietary intervention in targeting immunocytes and signaling pathways,which can adjust the polarization of macrophages,the function of T cells and the activities of various signaling pathways in order to seek the special medical purposes with safe,healthy and efficient lowering blood glucose,so as to provide ideas and programs for the dietary intervention of type 2 diabetes mellitus.
作者
蒲昕怡
张林铃
包斌
PU Xinyi;ZHANG Linling;BAO Bin(College of Food Science and Technology,Shanghai Ocean University,Shanghai 201306,China;Shanghai Engineering Research Center of Aquatic Product Processing and Preservation,Shanghai 201306,China;Institute of Marine Science,Shanghai Ocean University,Shanghai 201306,China)
出处
《食品工业科技》
CAS
北大核心
2023年第4期472-479,共8页
Science and Technology of Food Industry
基金
国家自然科学基金(82173731)
上海市自然科学基金(21ZR1427300)
国家自然科学基金外国青年学者研究基金(81750110548)。
关键词
2
型糖尿病
肥胖
炎症
免疫细胞
膳食干预
type 2 diabetes mellitus
obesity
inflammation
immunocytes
dietary intervention
