摘要
目的探究胆管癌转移途径的基本原理。方法选取临汾市人民医院2012年1月—2018年1月收治的32例胆管癌转移患者作为研究对象,设为观察组,另选取同期收治的32例胆管癌未转移患者作为对照,设为对照组,分别观察两组患者的细胞生物学特性、转移机制及术后复发率。结果32例胆管癌转移患者当中,器官与组织转移有22例,占比为68.75%;淋巴管转移有24例,占比为75.00%;肿瘤组织内血管转移有25例,占比为78.13%;神经周围间隙转移26例,占比为81.25%。观察组患者肿瘤血管密度(tumor microvessel density,TVD)值(122.65±19.17)高于对照组的(42.83±6.11);观察组患者神经周围间隙浸润(perineural invasiveness,PNI)值(0.74±0.05)高于对照组的(0.14±0.06),差异均有统计学意义(P<0.05)。观察组患者1年内复发率的73.09%高于对照组的11.54%;观察组患者3年内复发率的100%高于对照组的61.54%;观察组患者1年内死亡率的34.62%高于对照组的0,差异均有统计学意义(P<0.05);观察组患者3年内死亡率的100%与对照组相同。结论胆管癌患者术后,很容易出现淋巴管转移、器官与组织转移、肿瘤组织内血管转移及神经周围间隙转移,提升了患者病情的复发率,对患者生命健康带来巨大危害,医护人员应予以高度重视。
Objective To explore the basic principles of the metastasis pathway of cholangiocarcinoma.Methods A total of 32 patients with metastatic cholangiocarcinoma treated in Linfen People’s Hospital from January 2012 to January 2018 were selected as the research object,and they were set as the observation group.Another 32 patients with non metastatic cholangiocarcinoma treated in the same period were selected as the control group,and they were set as the control group.The cell biological characteristics,metastasis mechanism and postoperative recurrence rate of the two groups were observed respectively.Results Among 32 patients with cholangiocarcinoma metastasis,22 had organ and tissue metastasis,68.75%,24 lymphatic tube metastasis,75.00%,25vascular metastasis within tumor tissue,78.13%.26 peripheral nerve space metastasis,81.25%.The TVD(122.65±19.17)was higher than the B(42.83±6.11)and the A(0.737±0.049)than the B(0.139±0.046),and the differences were statistically significant(P<0.05).The recurrence rate of 73.09%of patients in the observation group within 1 year was higher than 11.54%in the observation group higher than 61.54%in the control group.34.62%in the observation group was higher than 0 in the control group,and the differences were statistically significant(P<0.05),and 100%mortality in the observation group was the same as in the control group.Conclusion After surgery,patients with cholangiocarcinoma are easy to appear lymphatic metastasis,organ and tissue metastasis,tumor metastasis of vascular tissue and peripheral nerve space metastasis,which improves the recurrence rate of patients’s condition and brings great harm to patient life and health,and medical staff should attach great attention to it.
作者
李华贤
李洲兴
张俊丽
LI Huaxian;LI Zhouxing;ZHANG Junli(Department of Medicine,Linfen Vocational and Technical College,Linfen Shanxi 041000,China;Department of Emergency,Linfen People's Hospital,Linfen Shanxi 041000,China)
出处
《中国卫生标准管理》
2023年第1期143-147,共5页
China Health Standard Management
关键词
胆管癌
转移途径
病理学检查
生物学特性
转移机制
肿瘤血管密度
cholangiocarcinoma
transfer pathway
pathological examination
biological characteristics
transfer mechanism
tumor vascular density
