摘要
目的分析食管癌新辅助放化疗预后影响因素及复发模式,并对其预后预测的重要进展进行综述。方法以“食管癌、新辅助放化疗、预后和预测”为关键词,检索PubMed以及CNKI等期刊全文数据库2010-2022年发表的相关文献。纳入标准:影响食管癌新辅助放化疗预后的因素,食管癌新辅助放化疗术后复发模式,预测食管癌新辅助放化疗预后的模型。根据纳入标准分析文献69篇。结果大量前瞻性或回顾性研究发现,环境因素与基因、遗传相互作用、手术相关因素及不同的复发模式均对食管癌新辅助放化疗的预后有重要影响。预后预测模型有助于筛选出新辅助治疗获益的患者,并且在结合影像组学特征后,表现出更高的预测精度。食管癌新辅助放化疗的预后预测取得了阶段性的成果,但是模型构建多基于简单的临床和影像学特征。结论综合遗传、生活环境、饮食习惯等多种因素及复发模式建立食管癌新辅助放化疗预后预测模型,将临床病理特征、分子生物学特征与影像学特征有效地结合,开展更加精准的预测,是提高食管癌生存的关键,有望助力食管癌新辅助放化疗的临床发展。
Objective To analyze prognostic factors and recurrence patterns of neoadjuvant chemoradiotherapy for esophageal cancer,and summarize the advances in prognosis prediction for esophageal cancer.Methods All references were searched in PubMed and CNKI retrieval system with the keywords of"esophageal cancer,neoadjuvant chemoradiotherapy,prognosis and prediction"from 2010to 2022.Inclusion criteria:(1)factors affecting the prognosis of neoadjuvant chemoradiotherapy for esophageal cancer;(2)recurrence patterns after neoadjuvant chemoradiotherapy for esophageal cancer;and(3)models for predicting the prognosis of neoadjuvant chemoradiotherapy for esophageal cancer.Totally 67literature was selected.Results A large number of prospective or retrospective clinical researches find that environmental factors interact with genes and heredity,and that surgery-related factors and different patterns of recurrence have important effects on the prognosis of neoadjuvant chemoradiotherapy for esophageal cancer.A prognostic prediction model helps filter patients who may benefit from neoadjuvant chemoradiotherapy and show higher prediction accuracy when combined with radiomics features.Initial achievements have been achieved in the prognostic prediction of neoadjuvant chemoradiotherapy for esophageal cancer;however,the construction of the model is mostly based on simple clinical and imaging features.Conclusions It is the key to establish a prognostic model of neoadjuvant chemoradiotherapy for esophageal cancer by combining various factors such as genetics,living environment,dietary habits and recurrence patterns,for improving the survival of esophageal cancer.An effective combination of clinicopathological features,molecular biological features and imaging features to carry out more accurate prediction is expected to help the clinical development of neoadjuvant chemoradiotherapy for esophageal cancer.
作者
张萌
李振江
尹勇
ZHANG Meng;LI Zhen-jiang;YIN Yong(Cheeloo College of Medicine,Shandong University,Jinan250012,China;Department of Radiation Oncology,Shandong Cancer Hospital and Institute,Shandong First Medical Universityand Shandong Academy of Medical Sciences,Jinan250117,China)
出处
《中华肿瘤防治杂志》
CAS
北大核心
2022年第20期1508-1516,共9页
Chinese Journal of Cancer Prevention and Treatment
基金
国家自然科学基金(82072094)
国家自然科学基金青年基金(82102173)。
关键词
食管癌
新辅助放化疗
预后
预测
综述文献
esophageal cancer
neoadjuvant chemoradiotherapy
prognostic
predict
review literature
