摘要
目的分析肝脏良性恶肿瘤诊断中低剂量超声造影与血清微小RNA-1469联合使用的价值。方法回顾性分析2017年1月—2020年1月在郑州市第七人民医院就诊的103例肝脏肿瘤患者的临床资料,按照肿瘤良恶性分为良性肿瘤组(50例)与恶性肿瘤组(53例)。所有患者于入院时进行低剂量超声造影检查,并检测血清miR-1469水平,评价低剂量超声造影联合血清miR-1469对肝脏肿瘤良恶性的诊断价值。结果良性肿瘤组超声造影的峰值强度[(127.84±14.59)dB]低于恶性肿瘤组[(186.36±18.14)dB,P<0.05],超声造影的达峰时间[(60.28±6.52)s]高于恶性肿瘤组[(40.75±4.87)s,P<0.05],血清miR-1469表达量(5.74±0.62)高于恶性肿瘤组(0.82±0.08,P<0.05)。ROC曲线分析显示,超声造影峰值强度和达峰时间分别以155.32 dB、42.34 s为最佳截断点,诊断肝脏恶性肿瘤的AUC分别为0.791、0.801,达峰时间的AUC更高;miR-1469诊断肝脏恶性肿瘤的最佳截断点为0.88;超声造影与miR-1469联合诊断的灵敏度、AUC、约登指数分别为74.46%、0.912和0.640。结论低剂量超声造影联合血清miR-1469可用于诊断肝脏肿瘤良恶性,诊断效能优于单独诊断,临床应用价值较高。
Objective To analyze the value of low dose contrast-enhanced ultrasound combined with serum microRNA-1469 in the diagnosis of benign and malignant neoplasms in liver.Methods A retrospective analysis of the clinical data of 103 patients with liver tumours who were admitted from January 2017 to January 2020 in Seventh People's Hospital of Zhengzhou was conducted.According to benign and malignant tumors,they were divided into benign tumor group(50 cases)and malignant tumor group(53 cases).Low-dose contrast-enhanced ultrasonography was performed at admission,and the level of serum miR-1469 was detected.The value of low-dose contrast-enhanced ultrasound combined with serum miR-1469 in the diagnosis of benign and malignant liver tumours was evaluated.Results The peak intensity of contrast-enhanced ultrasound in the benign tumour group[(127.84±14.59)dB]was lower than that in the malignant tumour group[(186.36±18.14)dB,P<0.05].In the benign tumour group,the peak time of contrast-enhanced ultrasound[(60.28±6.52)s]was higher than that in the malignant tumour group[(40.75±4.87)s,P<0.05],and the expression level of miR-1469(5.74±0.62)was higher than that of the malignant tumour group(0.82±0.08,P<0.05).ROC analysis showed that the peak intensity and peak time of contrast-enhanced ultrasound were 155.32 dB and 42.34 s,respectively.The area under the curve(AUC)of liver malignant tumours was 0.791 and 0.801,respectively,and the AUC of peak time was high.The best cut-off point of miR-1469 in the diagnosis of liver malignant tumours was 0.88.The sensitivity,AUC and Youden index of combined diagnosis of contrast-enhanced ultrasound combined with mir-1469 were 74.46%,0.912 and 0.640,respectively.Conclusion Low-dose contrast-enhanced ultrasound combined with serum miR-1469 can be used to diagnose benign and malignant liver tumours.The diagnostic efficiency is better than that of single diagnosis,and the clinical application value is higher.
作者
于慧娟
邢丽丽
杨帆
李广明
YU Hui-juan;XING Li-li;YANG Fan;LI Guang-ming(Department of Ultrasound Medical Imaging,the Seventh People's Hospital of Zhengzhou,Zhengzhou,Henan 450000,China;不详)
出处
《中华全科医学》
2023年第1期104-107,共4页
Chinese Journal of General Practice
基金
河南省医学科技攻关项目(2018020849)。
