摘要
目的:观察艾司西酞普兰联合奥氮平治疗抑郁症睡眠障碍患者的临床效果。方法:选取2019年1月至2021年12月鹤山市人民医院收治的抑郁症睡眠障碍患者60例作为研究对象,按照奇偶法分为观察组与对照组,每组30例。对照组采取艾司西酞普兰治疗,观察组在对照组治疗基础上加用奥氮平治疗,比较2组患者的治疗效果。结果:治疗后,2组患者匹兹堡睡眠质量指数(PSQI)评分和呼吸暂停低通气指数(AHI)值均明显降低,观察组患者PSQI评分及AHI指数值均低于对照组,2组比较差异均有统计学意义(均P<0.05);治疗后,2组患者总睡眠时间(TST)、实际睡眠时间(AST)、睡眠效率(SE)、睡眠潜伏期(SL)、非快速眼球运动睡眠时间的S2比较,差异均无统计学意义(均P>0.05);观察组的S1、觉醒指数(AI)比对照组更短,S3、S4、快速眼球运动睡眠时间(REM)比对照组更长,2组比较差异均有统计学意义(均P<0.05);观察组治疗有效率显著高于对照组,2组比较差异有统计学意义(P<0.05)。结论:艾司西酞普兰联合奥氮治疗抑郁症睡眠障碍患者疗效显著,可优化睡眠结构和质量,值得临床推广应用。
Objective:To observe the clinical effect of escitalopram combined with olanzapine in the treatment of depressive patients with sleep disorders.Methods:According to the odd even method,60 patients with depressive sleep disorder were divided into the observation group and the control group,with 30 cases in each group.The control group was treated with escitalopram alone.On the premise of this treatment,the observation group was matched with olanzapine,and the therapeutic effects of the two groups were compared.Results:After treatment,Pittsburgh Sleep Quality Index(PSQI)scores and apnea hypopnea index(AHI)values in the observation group and the control group decreased significantly,and the two indexes in the observation group decreased more than those in the control group(P s<0.05).After treatment,there was no significant difference in total sleep time(TST),actual sleep time(AST),sleep efficiency(SE),sleep latency(SL),S2 in non-rapid eye movement between the two groups(P s>0.05).Compared with the control group,S1 and arousal index(AI)in the observation group were shorter(P<0.05),and S3,S4,rapid eye movement(REM)were longer(P s<0.05).In terms of treatment efficiency,the observation group was also significantly higher than the control group(P<0.05).Conclusion:Escitalopram combined with olanzapine has a significant effect on the treatment of depression patients with sleep disorders,which can optimize the sleep structure and quality,and is worthy of extensive promotion in clinical practice.
作者
吕华辉
黄碧波
LYU Huahui;HUANG Bibo(Pharmacy Department of Heshan People′s Hospital,Heshan 529700,China)
出处
《世界睡眠医学杂志》
2022年第12期2258-2260,共3页
World Journal of Sleep Medicine
