摘要
新冠疫情暴发对全球公共卫生构成了巨大威胁,病毒的快速、准确诊断对新冠疫情防控具有至关重要的作用。近年来,以纳米材料为基础的电化学传感技术在快速、高灵敏度/高特异性分子诊断方面显示出巨大的潜力。本文简要介绍了新型冠状病毒(SARS-CoV-2)的结构特征及常规检测方法,总结了电化学生物检测相关传感特点和机制。在此基础上,详细评述了金纳米材料、氧化物纳米材料、碳基纳米材料等为基础的电化学传感器用于快速、准确检测新冠病毒的研究进展。最后,展望了基于电化学传感技术在未来生物分子诊断中的应用。
The pandemic outbreak of COVID-19 has posed a threat to public health globally,and rapid and accurate identification of the viruses is crucial for controlling COVID-19.In recent years,nanomaterial-based electrochemical sensing techniques hold immense potential for molecular diagnosis with high sensitivity and specificity.In this review,we briefly introduced the structural characteristics and routine detection methods of SARS-CoV-2,then summarized the associated properties and mechanisms of the electrochemical biosensing methods.On the above basis,the research progress of electrochemical biosensors based on gold nanomaterials,oxide nanomaterials,carbon-based nanomaterials and other nanomaterials for rapid and accurate detection of virus were reviewed.Finally,the future applications of nanomaterial-based biosensors for biomolecular diagnostics were pointed out.
作者
刘瑶
尤勋海
赵冰
罗晓莹
陈星
LIU Yao;YOU Xunhai;ZHAO Bing;LUO Xiaoying;CHEN Xing(Institute of Industry and Equipment Technology,Hefei University of Technology,Hefei 230009,China;School of Resources and Environmental Engineering,Hefei University of Technology,Hefei 230009,China;School of Materials Science and Engineering,Hefei University of Technology,Hefei 230009,China;State Key Laboratory of Oncogenes and Related Genes,Shanghai Cancer Institute,Renji Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 200032,China)
出处
《无机材料学报》
SCIE
EI
CAS
CSCD
北大核心
2023年第1期32-42,共11页
Journal of Inorganic Materials
基金
国家重点研发计划(SQ2021YFE011305)。
