摘要
目的分析急诊治疗中采取解磷定联合早期血液灌流治疗有机磷农药中毒的效果。方法选取2019年10月至2021年9月武汉市新洲区人民医院收治的有机磷农药中毒患者60例为研究对象,以随机双盲法分为对照组(n=30)和观察组(n=30),对照组实施常规急诊治疗,观察组采取常规急诊治疗联合早期血流灌流治疗。比较两组治愈率、病死率、恢复时间、用药情况、并发症、胆碱酯酶指标。结果观察组治愈率高于对照组,病死率低于对照组,差异有统计学意义(P<0.05);观察组患者昏迷时间、阿托品化时间、胆碱酯酶恢复时间和住院时间均短于对照组,差异有统计学意义(P<0.05);观察组阿托品及解磷定治疗中用量均少于对照组,差异有统计学意义(P<0.05);观察组疾病并发症总发生率低于对照组,差异有统计学意义(P<0.05);治疗后24、48、72 h,观察组胆碱酯酶水平均高于对照组,差异有统计学意义(P<0.05)。结论急诊治疗有机磷农药中毒中,以解磷定及早期血液灌流治疗,患者可在短时间内恢复生命体征。可减少药物用量,能够促使胆碱酯酶尽早恢复至正常值,可降低并发症发生风险,降低病死率。
Objective To analyze the efficacy of pralidoxime combined with early hemoperfusion in the emergency treatment of organophosphorus pesticide poisoning.Methods A total of 60 patients with organophosphorus pesticide poisoning admitted to Wuhan Xinzhou District People’s Hospital from October 2019 to September 2021 were selected as subjects for this study.They were divided into the control group(n=30)and observation group(n=30)by a randomized double-blind method,the control group receiving conventional emergency treatment and the observation group receiving combined early hemoperfusion and conventional emergency treatment.The cure rate,mortality rate,recovery time,medication,complications,and cholinesterase indexes were compared between the two groups.Results The cure rate was higher and the mortality rate was lower in the observation group than in the control group,with statistically significant differences(P<0.05).The coma time,atropinization time,cholinesterase recovery time,and length of hospital stay were shorter in the observation group than in the control group,with statistically significant differences(P<0.05).The dosages of atropin and pralidoxime used in the observation group were less than those in the control group,with statistically significant differences(P<0.05).The total incidence of complications in the observation group was lower than that in the control group,with statistically significant difference(P<0.05).The cholinesterase levels in the observation group were higher than those in the control group at 24 h,48 h and 72 h after treatment,with statistically significant differences(P<0.05).Conclusion Patients with organophosphorus pesticide poisoning treated by emergency treatment with pralidoxime and early hemoperfusion can recover their vital signs in a short period of time.Besides,this combined treatment reduces the dosage of drugs,promotes the early recovery of cholinesterase to normal values,and reduces the risk of complications and mortality.
作者
袁刚
YUAN Gang(Department of Emergency Medicine,Wuhan Xinzhou District People’s Hospital,Hubei,Wuhan 430400,China)
出处
《中国医药科学》
2023年第3期187-191,共5页
China Medicine And Pharmacy
关键词
有机磷农药中毒
急诊治疗
解磷定
早期血液灌流
治愈率
并发症
Organophosphorus pesticide poisoning
Emergency treatment
Pralidoxime
Early hemoperfusion
Cure rate
Complications
