摘要
目的探讨肺炎支原体IgM抗体(MP-IgM)、降钙素原(PCT)、超敏C反应蛋白(hs-CRP)联合检测在儿童肺炎支原体感染中的应用及其诊断价值。方法选取2022年8月至12月南京江北医院儿科就诊的肺炎支原体感染患儿58例为感染组,另选取同期体检健康儿童59例为对照组。分析hs-CRP、PCT及MP-IgM联合检测在儿童肺炎支原体感染中的诊断价值。结果与对照组相比,感染组PCT和hs-CRP水平均高于对照组(P<0.05)。感染组MP-IgM阳性率高于对照组(75.9%vs 10.2%,P<0.05)。MP-IgM诊断MP感染的灵敏度为75.9%,特异性为89.8%,阳性预测值为88.0%,阴性预测值为79.1%,准确度为82.9%。采用ROC曲线分析PCT和hs-CRP在肺炎支原体感染时,PCT和hs-CRP的曲线下面积(AUC)分别为0.672、0.640,与MP-IgM联合检测诊断小儿肺炎支原体感染灵敏度为91.3%,特异性为88.1%,阳性预测值为88.3%,阴性预测值为91.1%,准确度为89.7%。结论PCT、hs-CRP对儿童肺炎支原体感染的诊断有一定的应用价值,与传统的MP-IgM检测联合应用可有效提高检测阳性率,联合检测的灵敏度、阴性预测值、准确度均高于单独MP-IgM检测,可弥补单纯MP-IgM检测的不足。
Objective To investigate the diagnostic value of Mycoplasma pneumoniae IgM antibody(MP-IgM),procalcitonin(PCT)and hypersensitive C-reactive protein(hs-CRP)combined detection in children with Mycoplasma pneumoniae infection.Methods Fifty-eight children with Mycoplasma pneumoniae infection in Nanjing Jiangbei Hospital from August 2022 to December 2022 were selected as the infection group,and 59 healthy children in the same period were selected as the control group.The diagnostic value of combined detection of hs-CRP,PCT and MP-IgM in children with Mycoplasma pneumoniae infection was compared and analyzed.Results Compared with the control group,the levels of PCT and hs-CRP in the infection group were higher than those in the control group(P<0.05).The positive rate of MP-IgM in the infection group was higher than that in the control group(75.9%vs 10.2%,P<0.05).The sensitivity,specificity,positive predictive value,negative predictive value and accuracy of MP-IgM in the diagnosis of MP infection were 75.9%,89.8%,88.0%,79.1%and 82.9%,respectively.The area under the curve(AUC)of PCT and hs-CRP were 0.672 and 0.640 respectively when analyzed by ROC curve.The sensitivity,specificity,positive predictive value,negative predictive value and accuracy of combined detection of PCT and hs-CRP with MP-IgM were 91.3%,88.1%,88.3%,91.1%and 89.7%respectively.Conclusions PCT and hs-CRP have certain application value in the diagnosis of Mycoplasma pneumoniae infection in children.The combination of PCT and hs-CRP with traditional MP-IgM detection can effectively improve the positive rate of detection.The sensitivity,negative predictive value and accuracy of the combined detection are higher than that of single MP-IgM detection,which can make up for the deficiency of the positive rate of pure MP-IgM detection.
作者
杨帆
张仁和
徐新润
陈久应
YANG Fan;ZHANG Ren-he;XU Xin-run;CHEN Jiu-ying(Clinical Laboratory,Maternal and Child Health Care Institute,Jiangbei New District Public Health Service Center,Nanjing,Jiangsu 210048,China)
出处
《中国临床研究》
CAS
2023年第2期295-298,共4页
Chinese Journal of Clinical Research
关键词
肺炎支原体
肺炎支原体IGM抗体
降钙素原
超敏C反应蛋白
肺炎
儿童
Mycoplasma pneumoniae
Mycoplasma pneumoniae IgM antibody
Procalcitonin
Hypersensitive C-reactive protein
Pneumonia
Children
