摘要
中药可抑制肺癌干细胞(LCSCs)增殖、侵袭、迁移及耐药蛋白表达,并诱导细胞凋亡,延缓自我更新,还能通过干预其生态位、免疫微环境及有氧糖酵解等多途径发挥抗肿瘤效应,其中涉及的生物标志物主要包括CD133、CD44、ALDH及ABCG2等,而相关的信号通路有Wnt/β-catenin、Hedgehog、Notch等。中医药干预LCSCs的研究总体偏少,多集中在基础研究,且选取的实验指标重复率高,涉及的细胞类型与信号通路较少;临床试验相对缺乏,欠缺与基础实验有机衔接。今后还需提高研究质量,并深入研究具有抗肺癌干细胞效应的中药,以推动肺癌的精准化治疗。
Chinese materia medica can inhibit the proliferation,invasion,migration and expression of drug-resistant proteins of lung cancer stem cells(LCSCs),and induce apoptosis and delay self-renewal,as well as exert anti-tumor effects by interfering with their ecological niche,immune microenvironment and aerobic glycolysis,etc.The biomarkers involved mainly include CD133,CD44,ALDH and ABCG2,while the related signaling pathways are Wnt/β-catenin,Hedgehog,and Notch.The research on the intervention of LCSCs by Traditional Chinese Medicine(TCM)is generally few,mostly concentrated in basic research,and the selected experimental indicators have a high repetition rate,involving fewer cell types and signaling pathways;there is a relative lack of clinical trials,which lack an organic connection with basic experiments.In the future,the quality of research is expected to be improved,and in-depth study of TCM with anti-lung cancer stem cell effect should be carried out,with the purpose to promote the precise treatment of lung cancer.
作者
滕港
张芮
周静
张念志
Teng Gang;Zhang Rui;Zhou Jing;Zhang Nianzhi(Master Degree Student of Grade 2020,Anhui University of Chinese Medicine,Hefei 230031,China;Doctoral Degree Student of Grade 2020,Anhui University of Chinese Medicine,Hefei 230031,China;Doctoral Degree Student of Grade 2022,Anhui University of Chinese Medicine,Hefei 230031,China;Department of Respiratory Medicine,the First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230031,China)
出处
《国际中医中药杂志》
2023年第2期253-256,F0003,共5页
International Journal of Traditional Chinese Medicine
基金
安徽省中医肺病临床医学研究中心项目(皖科社〔2020〕41号)。
关键词
癌
肺癌干细胞
中药
生物标志物
信号通路
综述
Carcinoma
Lung cancer stem cells
Traditional Chinese Medicine
Biomarkers
Signaling Pathways
Review
