摘要
结合海藻酸钠、五羟色胺在止血及伤口愈合方面的优势,以及水凝胶复杂网络结构的物理屏蔽作用,本文以海藻酸钠与五羟色胺为原料,在辣根过氧化物酶和H2O2的催化下制备了一种新型可注射水凝胶。通过取代反应制备得到海藻酸钠-五羟色胺聚合物,并通过傅里叶红外光谱和紫外-可见光吸收光谱对海藻酸钠-五羟色胺聚合物进行了表征。通过实验研究了双氧水浓度对其凝胶时间、溶胀度、力学性能、皮肤贴附性的影响,结果表明,在不同双氧水浓度(10 mmol/L~40 mmol/L)条件下形成的水凝胶表现出良好的溶胀度(18 g/g~33 g/g),较短的凝胶时间(40 s~80 s),且可通过改变双氧水的浓度来调整其凝胶时间、溶胀度以及力学性能。扫描电镜结果表明该水凝胶具有三维多孔结构,皮肤粘附实验显示该水凝胶具有良好的皮肤贴合能力,而且干燥后也易从皮肤上脱落。
Combining the advantage of sodium alginate and serotonin in hematischesis and wound healing with the physical shielding effect of complex network structure of hydrogel, we used sodium alginate and serotonin as raw materials, and prepared a new injectable hydrogel under the catalysis of horseradish peroxidase and H2O2. Sodium alginate-serotonin was prepared by substitution reaction, and sodium alginate-serotonin was characterized by Fourier transform infrared spectroscopy and ultraviolet-visible absorption spectrum. The effects of hydrogen peroxide concentration on its gel time, swelling degree, mechanical properties and skin adhesion were studied by experiment, and the results show that the hydrogels formed under different hydrogen peroxide concentrations(10 mmol/L-40 mmol/L) show good swelling degree(18 g/g-33 g/g), shorter gel time(40 s-80 s), and the gel time, swelling degree and mechanical properties can be adjusted by changing the concentration of hydrogen peroxide. The results of scanning electron microscope show that the hydrogel has three-dimensional porous structure. Skin adhesion experiments show that the hydrogel has good skin adhesion ability and is easy to fall off the skin after drying.
作者
邓水明
何昊东
李颖
王芳
郭建峰
DENG Shuiming;HE Haodong;LI Ying;WANG Fang;GUO Jianfeng(School of Chemistry and Chemical Engineering,North University of China,Taiyuan 030051,China)
出处
《中北大学学报（自然科学版）》
CAS
2023年第1期72-78,共7页
Journal of North University of China(Natural Science Edition)
基金
山西省重点研发计划(国际科技合作)项目(201803D421017)。
关键词
可注射水凝胶
海藻酸钠
五羟色胺
自愈
injectable hydrogel
sodium alginate
serotonin
self-healing
