摘要
肌肉生长抑制因子Myostatin由肌细胞分泌,是肌肉生长和再生的负调节因子。在本文中,我们探讨了Myostatin在骨骼代谢、骨骼生物力学和肌肉发展过程中,影响骨质疏松症的原因,以及在骨骼代谢过程中的复杂变化。例如在体外实验中,Myostatin抑制成骨细胞的分化并以剂量依赖的方式刺激破骨细胞的活性。缺少Myostatin的小鼠破骨细胞数量减少,皮质厚度增加,胫骨皮质组织矿物质密度增加。胫骨中的皮质骨密度增加,而椎体骨密度增加。虽然肌肉骨骼系统是最常见的增龄性退化的主要原因,但是骨质疏松症究其原因,在于骨重建的基本过程如骨形成和骨吸收的精密程序化过程中,成骨细胞与破骨细胞的分化或功能如何是骨代谢平衡的重要因素。另外,需进一步研究阐明肌肉生长抑制因子在骨代谢中的调节作用。
Myostatin is a myokine,secreted by myoblasts and is a negative regulator of muscle growth and regeneration.In this paper,we explore the role of Myostatin affects osteoporosis during skeletal metabolism,skeletal biomechanics and muscle development,as well as the complex changes during skeletal metabolism.In vitro,for example,Myostatin inhibits osteoblast differentiation and stimulates osteoclast activity in a dose-dependent manner.Myostatin-deficient mice showed reduced osteoclast numbers,increased cortical thickness,and increased mineral density of tibial cortical tissue.Cortical bone density was increased in the tibia,while vertebral bone density was increased.Although the musculoskeletal system is the most common major cause of ageing degeneration,osteoporosis is explained by how the differentiation or function of osteoblasts and osteoclasts is an important factor in the balance of bone metabolism during the sophisticated programming of basic processes of bone reconstruction such as bone formation and bone resorption.In addition,further studies are needed to elucidate the regulatory role of Myostatin in bone metabolism.
作者
冬梅
金淑霞
林靖
阿斯楞
DONG Mei;JIN Shuxia;LIN Jing;Asileng(Department of Osteoporosis,The Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010013,China;Department of Clinical Nutrition,The Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China;Inner Mongolia Medical University,Hohhot 010059,China)
出处
《内蒙古医科大学学报》
2022年第5期548-552,共5页
Journal of Inner Mongolia Medical University
基金
内蒙古自治区自然科学基金项目(2018MS08111)。
