摘要
甘油三酯-葡萄糖(triglyceride-glucose,TyG)指数与体重指数(body mass index,BMI)的乘积(TyG-BMI)与老年人2型糖尿病(type 2 diabetes mellitus,T_(2)DM)之间的关系尚未完全了解。为了探讨中国60岁以上老年人群TyG-BMI与T_(2)DM发病风险的相关性,基于中国一个健康检查筛查项目的数据库,根据TyG-BMI连续变量和四分位数组对参与者进行分层(Q1组~Q4组)。采用Kaplan-Meier方法估计T_(2)DM各四分位数组的累积发生率;采用Cox比例风险模型观察随访期间TyG-BMI对T_(2)DM风险的独立影响;通过亚组分析进一步验证结果的可信度。随访期间,在24665名60岁以上人群中,共记录到1533例新发T_(2)DM病例。结果表明,TyG-BMI每增加一个单位,T_(2)DM发生风险变为原来的1.014倍[风险比(hazard ratio,HR)=1.014;95%置信区间(confidence interval,CI):1.013~1.015;P<0.001]。调整混杂因素后,TyG-BMI每升高一个单位,T_(2)DM患病风险增高(HR=1.032;95%CI:1.028~1.035;P<0.001)。TyG-BMI较高的四分位组(Q2~Q4)与最低四分位组(Q1)相比,T_(2)DM的风险也更高,HR分别为2.062、2.903和5.187。亚组分析显示,在男性和女性亚组中,TyG-BMI每增加一个单位,T_(2)DM的发病率变为原来的1.038倍(95%CI:1.032~1.045)和1.028倍(95%CI:1.024~1.033);在小于75岁和大于或等于75岁的人群中,TyG-BMI每增加一个单位,T_(2)DM的发病率变为原来的1.029倍(95%CI:1.025~1.034)和1.040倍(95%CI:1.031~1.049)。可见TyG-BMI与中国60岁以上成人发生T_(2)DM的风险独立相关,TyG-BMI可能是一个有前景的老年人群T_(2)DM的预测指标。
The relationship between the triglyceride-glucose(TyG)index multiply the body mass index(BMI)(TyG-BMI)and the elderly type 2 diabetes(T_(2)DM)is not fully understood.In order to explore the correlation between TyG-BMI and the risk of T_(2)DM in Chinese elderly people over 60 years old,based on the database of a health examination and screening program in China,participants were stratified according to TyG-BMI continuous variables and quartile arrays(Q1 group~Q4 group).Kaplan-Meier method was used to estimate the cumulative incidence of each quartile array of T_(2)DM.Cox proportional hazards model was used to observe the independent effect of TyG-BMI on T_(2)DM risk during follow-up.The reliability of the results was further verified by subgroup analysis.During the follow-up period,1533 new cases of T_(2)DM were recorded in 24665 people over 60 years old.The results show that the risk of T_(2)DM increases 1.014 times for each unit of TyG-BMI(HR=1.014,95%CI:1.013~1.015,P<0.001).After adjusting for confounding factors,each unit increase in TyG-BMI increases the risk of T_(2)DM(HR=1.032,95%CI:1.028~1.035,P<0.001).The quartile group with higher TyG-BMI(Q2~Q4)also has a higher risk of T_(2)DM than the lowest quartile(Q1)(HR=2.062,2.903 and 5.187,respectively).Subgroup analysis shows that in each subgroup of men and women,the incidence rate of T_(2)DM increases to 1.038 times(95%CI:1.032~1.045)and 1.028 times(95%CI:1.024~1.033)of TyG-BMI in every unit.Among people aged less than 75 and over 75,TyG-BMI incidence rate increases to 1.029 times(95%CI:1.025~1.034)and 1.040 times(95%CI:1.031~1.049)of T_(2)DM per unit.It can be seen that TyG-BMI is independently related to the risk of T_(2)DM in Chinese adults over 60 years old.TyG-BMI may be a promising predictor of T_(2)DM in the elderly.
作者
雷庆华
李军华
霍燕飞
段丽华
胡艳艳
王闪闪
LEI Qing-hua;LI Jun-hua;HUO Yan-fei;DUAN Li-hua;HU Yan-yan;WANG Shan-shan(Physical Examination Center,Handan Central Hospital,Handan 056000,China;Department of Ultrasonic Diagnosis,Handan Central Hospital,Handan 056000,China)
出处
《科学技术与工程》
北大核心
2023年第5期1882-1887,共6页
Science Technology and Engineering
基金
邯郸市科学技术研究与发展计划(22422083010ZC)。
