摘要
目的观察针刺、刺血疗法配合徐长卿合剂治疗慢性自发性荨麻疹血虚风燥证的临床疗效及其对免疫球蛋白E(immunoglobulin E,IgE)、嗜酸性粒细胞(eosinophils,EOS)水平的影响。方法将83例慢性自发性荨麻疹血虚风燥证患者随机分为治疗组(42例)和对照组(41例)。治疗组采用针刺、刺血疗法配合徐长卿合剂口服治疗,对照组采用口服盐酸左西替利嗪片治疗。观察两组治疗前后1周荨麻疹活动度(urticaria activity score over 7 days,UAS7)、皮肤病生活质量指数(dermatology life quality index,DLQI)、荨麻疹控制程度测试(urticaria control test,UCT)评分、血清IgE水平、血EOS百分比及绝对值的变化情况,并比较两组临床疗效。结果两组治疗后UAS7各项评分、DLQI评分及血清IgE水平均较同组治疗前显著下降,UCT评分显著上升,差异均有统计学意义(P<0.05)。治疗组治疗后UAS7各项评分、DLQI评分、UCT评分及血清IgE水平与对照组比较,差异均有统计学意义(P<0.05)。两组治疗后血EOS百分比、绝对值组内及组间比较,差异均无统计学意义(P>0.05)。治疗组总有效率为95.0%,明显高于对照组的80.0%(P<0.05)。结论针刺、刺血疗法配合徐长卿合剂治疗慢性自发性荨麻疹血虚风燥证疗效确切,能下调IgE、EOS水平,改善患者生活质量及免疫状态。
Objective To observe the clinical efficacy of acupuncture and pricking bloodletting therapy plus Xuchangqing mixture for chronic spontaneous urticaria with blood deficiency and wind dryness syndrome and its effect on immunoglobulin E(IgE)and eosinophil(EOS)levels.Method Eighty-three patients suffering from chronic spontaneous urticaria with blood deficiency and wind dryness syndrome were randomized to a treatment group(42 cases)and a control group(41 cases).The treatment group received acupuncture and pricking bloodletting therapy plus oral administration of Xuchangqing mixture and the control group,oral administration of levocetirizine hydrochloride pills.The urticaria activity score over 7 days(UAS7)score,the dermatology life quality index(DLQI)score,the urticaria control test(UCT)score,serum IgE levels,and blood EOS percentage and absolute value were observed in the two groups one week before and after treatment.The clinical therapeutic effects were compared between the two groups.Result The UAS7 item scores,the DLQI score and serum IgE levels decreased significantly and UCT score increased significantly in the two groups after treatment compared with before,with statistically significant differences(P<0.05).Post-treatment UAS7 item scores,DLQI score,UCT score and IgE levels had statistically significant differences between the treatment and control groups(P<0.05).In the two groups,post-treatment within-group and between-group comparisons of blood EOS percentages and absolute values showed no statistically significant differences(P>0.05).The total efficacy rate was 95.0%in the treatment group,which was significantly higher than 80.0%in the control group(P<0.05).Conclusion Acupuncture and pricking bloodletting therapy plus Xuchangqing mixture has a definite therapeutic effect on chronic spontaneous urticaria with blood deficiency and wind dryness syndrome.It can downregulate IgE and EOS levels and improve the patients’quality of life and state of immunity.
作者
李钰
鄢德政
王飞虎
李悦
王钏
张红星
LI Yu;YAN Dezheng;WANG Feihu;LI Yue;WANG Chuan;ZHANG Hongxing(Hubei University of Chinese Medicine,Wuhan 430065,China;Hubei University of Traditional Chinese Medicine Wuhan Hospital of Traditional Chinese and Western Medicine,Wuhan 430022,China)
出处
《上海针灸杂志》
CSCD
2023年第3期268-273,共6页
Shanghai Journal of Acupuncture and Moxibustion
基金
十三五国家重点研发计划项目(2017YFC1703605)。
关键词
针刺疗法
放血疗法
针药并用
荨麻疹
免疫球蛋白E
嗜酸性粒细胞
血虚风燥
Acupuncture therapy
Bloodletting therapy
Acupuncture medication combined
Urticaria
Immunoglobulin E
Eosinophil
Blood deficiency and wind dryness
