摘要
目的 分析阿司匹林+氯吡格雷治疗脑梗死的临床价值。方法 方便选择2019年6月—2022年5月在邳州市人民医院进行治疗的脑梗死患者82例为研究对象,依据随机数表法分为对照组(41例,阿司匹林治疗)、观察组(41例,阿司匹林+氯吡格雷治疗)。对比两组治疗效果、不良反应发生率、神经功能、自理能力、凝血指标及炎症因子水平。结果 观察组治疗效果(95.12%)高于对照组(75.61%),差异有统计学意义(χ^(2)=6.248,P<0.05);治疗后,观察组NIHSS评分为(4.33±0.92)分,低于对照组的(5.45±1.03)分,Barthel指数为(69.13±6.55)分,高于对照组的(61.65±7.42)分,差异有统计学意义(t=5.193、4.839,P<0.05);治疗后,观察组凝血指标(FIB、PT、APTT、TT)均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组C反应蛋白(CRP)水平低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率(7.32%)与对照组(4.88%)比较,差异无统计学意义(χ^(2)=0.000,P>0.05)。结论 阿司匹林+氯吡格雷治疗脑梗死效果显著,可有效改善患者神经功能及机体功能,且用药安全性较高。
Objective To analyze the clinical value of aspirin+clopidogrel in the treatment of cerebral infarction.Methods 82 patients with cerebral infarction who were treated in Pizhou People's Hospital from June 2019 to May 2022 were conveniently selected as the study subjects.According to random number table method,they were divided into control group(41 cases,aspirin treatment)and observation group(41 cases,aspirin+clopidogrel treatment).The therapeutic effect,incidence of adverse reactions,neurological function,self-care ability,coagulation index and in⁃flammatory factors level were compared between the two groups.Results The therapeutic effect of observation group(95.12%)was higher than that of control group(75.61%),and the difference was statistically significant(χ^(2)=6.248,P<0.05);after treatment,NIHSS score of the observation group was(4.33±0.92)points,which was lower than that of the control group(5.45±1.03)points,Barthel index was(69.13±6.55)points,higher than that of control group(61.65±7.42)points,the difference was statistically significant(t=5.193,4.839,P<0.05);after treatment,the coagulation in⁃dexes(FIB,PT,APTT,TT)in observation group were lower than those in control group,the difference was statistically significant(P<0.05);after treatment,the level of C-reactive protein(CRP)in observation group was lower than that in control group,the difference was statistically significant(P<0.05);there was no statistically significant difference in the incidence of adverse reactions between the observation group(7.32%)and the control group(4.88%)(χ^(2)=0.000,P>0.05).Conclusion Aspirin+clopidogrel has a significant effect in the treatment of cerebral infarction,which can effectively improve the neurological function and body function of patients,and the drug is safe.
作者
石晨
索超远
纪祥辉
SHI Chen;SUO Chaoyuan;JI Xianghui(Department of Neurology,Pizhou People's Hospital,Pizhou,Jiangsu Province,221300 China)
出处
《中外医疗》
2022年第32期154-158,共5页
China & Foreign Medical Treatment
关键词
阿司匹林
氯吡格雷
脑梗死
神经功能
不良反应
Aspirin
Clopidogrel
Cerebral infarction
Neural function
Adverse reaction
