摘要
快速有效的止血和创面愈合对于挽救生命和提高生活质量至关重要。目前,传统的止血和促进伤口愈合材料效果有限,存在组织黏附效果不理想、免疫原性,二次损伤和感染风险等局限性,故亟待开发新型高效的材料。蛋白质基水凝胶因生物相容性好、可降解、可注射、机械性能可调、可湿粘接,在止血和促进伤口愈合领域受到越来越多的关注。笔者就蛋白质基水凝胶的定义及各种蛋白质基水凝胶止血和促进创面愈合的研究进展进行综述,为创面修复领域应用蛋白质基水凝胶提供参考。
Rapid and effective hemostasis and wound healing are essential for life saving and improved quality of life.At present,traditional materials for hemostasis and wound healing have limited effects,with limitations such as unsatisfactory tissue adhesion effect,immunogenicity,secondary damage and infection risk,so it is urgent to develop new and efficient materials.Protein‑based hydrogels have attracted more and more attention in the field of hemostasis and wound healing because of their good biocompatibility,biodegradability,injectability,adjustable mechanical properties and wet bonding.The authors review the definition of protein‑based hydrogels and the research progress in various protein‑based hydrogels in promotion of hemostasis and wound healing,in order to provide a reference for the application of protein‑based hydrogels in wound repair.
作者
王晓萍
陈玉琴
张曦木
Wang Xiaoping;Chen Yuqin;Zhang Ximu(Department of Preventive Dentistry,Stomatological Hospital of Chongqing Medical University,Chongqing 401120,China;Department of Periodontics,Stomatological Hospital of Chongqing Medical University,Chongqing 401120,China;Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences,Chongqing 401120,China;Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education,Chongqing 401120,China)
出处
《中华创伤杂志》
CAS
CSCD
北大核心
2023年第2期165-170,共6页
Chinese Journal of Trauma
基金
国家自然科学基金(32070826)
重庆市科卫联合医学科研项目(2020GDRC017)
重庆医科大学未来医学青年创新团队计划(W075)。
关键词
止血
伤口愈合
蛋白质基水凝胶
Hemostasis
Wound healing
Protein‑based hydrogels
