摘要
目的分析阿仑膦酸钠联合钙制剂治疗绝经后骨质疏松症患者临床效果及炎症因子的影响。方法选取72例绝经后骨质疏松症患者,按照治疗方法不同分为对照组与研究组,每组36例。对照组行阿仑膦酸钠治疗,研究组行阿仑膦酸钠联合钙制剂治疗。比较两组临床效果、炎症因子变化情况。结果研究组治疗总有效率为97.22%,显著高于对照组的80.56%,差异有统计学意义(P<0.05)。治疗前,两组血清白介素-4(IL-4)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及超敏C反应蛋白(hs-CRP)水平比较,差异无统计学意义(P>0.05);治疗后,两组IL-4、IL-6、TNF-α及hs-CRP水平均低于治疗前,且研究组明显低于对照组,差异具有统计学意义(P<0.05)。结论阿仑膦酸钠联合钙制剂可提高绝经后骨质疏松症患者的临床治疗效果,调节患者炎症因子水平,值得临床推广与应用。
Objective To analyze the clinical effect of alendronate sodium combined with calcium preparation in the treatment of postmenopausal osteoporosis and the influence of inflammatory factors.Methods 72 patients with postmenopausal osteoporosis were selected and divided into control group and study group according to different treatment methods,There were 36 patients in each group.The control group was treated with alendronate sodium and the study group was treated with alendronate sodium combined with calcium preparation.The clinical effect and changes of inflammatory factors were compared between the two groups.Results The total effective rate of the study group was 97.22%,significantly higher than that of the control group(80.56%),and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in serum levels of interleukin-4(IL-4),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and hypersensitive C-reactive protein(hs-CRP)between 2 groups(P>0.05).After treatment,the levels of IL-4,IL-6,TNF-α and hs-CRP in 2 groups were lower than before,and the study group was significantly lower than the control group,the difference was statistically significant(P<0.05).Conclusion Alendronate sodium combined with calcium preparation can improve the clinical therapeutic effect of postmenopausal osteoporosis patients,regulate the level of inflammatory factors in patients,worthy of clinical promotion and application.
作者
毛媛媛
张震
刘尊国
Mao Yuanyuan;Zhang Zhen;Liu Zunguo(Department of Geriatrics and Special Needs Medicine,General Hospital ofNingxia Medical University,Yinchuan 750004,China)
出处
《实用妇科内分泌电子杂志》
2022年第28期43-45,共3页
Electronic Journal of Practical Gynecological Endocrinology
关键词
阿仑膦酸钠
钙制剂
绝经后骨质疏松症
临床疗效
炎症因子
Alendronate sodium
Calcium preparation
Postmenopal osteoporosis
Clinical effect
Inflammatory factors
