摘要
蛋白多肽类及多糖类成分是中药中不可或缺的大分子活性成分群,经传统加热煎煮后广泛存在于中药汤剂。然而这些大分子成分经口服给药通常被认为受胃肠道消化降解而无法以原型吸收或起效,这一观点与汤药在临床上的实际疗效不相吻合。现代研究认为大分子成分群在汤药煎煮过程中出现了新的物相结构并发挥效应,但中药成分间相互作用引起的相态变化规律及其物相结构与效应之间的联系有待进一步研究。基于此,该文回顾了中药大分子成分的口服吸收研究现状,从物相结构的视角分析中药大分子存在形式与吸收起效的内在联系,并展望了以物相结构为核心的中药大分子口服吸收起效研究模式,为未来相关研究提供新思路和新方法。
Protein polypeptides and polysaccharides,the indispensable macromolecular active components in traditional Chinese medicine,are widely found in Chinese medicine decoction after the decoction of traditional Chinese medicine.However,through oral administration,these macromolecules are digested by the stomach and intestine and thus fail to be absorbed in prototype.This is inconsistent with the actual clinical efficacy of Chinese medicine decoction.According to modern research,new phase structures and effects of the macromolecules emerge during the decoction of traditional Chinese medicine,but the phase change law caused by the interaction among the components of traditional Chinese medicine and the relationship between phase structure and effect are still unclear.Thus,this study reviewed the oral absorption of macromolecular components of traditional Chinese medicine,analyzed the internal relationship of the form of macromolecules in traditional Chinese medicine with the absorption and effect based on phase structure,and summarized the research mode of oral absorption and effect of macromolecules in traditional Chinese medicine with phase structures as the core,providing new ideas and methods for future research.
作者
肖航
黄菊
孟祥瑞
张怡宁
李静
马莉
XIAO Hang;HUANG Ju;MENG Xiang-rui;ZHANG Yi-ning;LI Jing;MA Li(College of Traditional Chinese Medicine,Capital Medical University,Beijing 100069,China;TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2023年第2期285-291,共7页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(82074020)
四川省科技计划项目(2022YFG0145)
北京市教育委员会科学研究计划项目(KM201910025021)。
关键词
结构中药学
蛋白肽类
多糖
口服吸收
起效形式
物相结构
构效关系
structural traditional Chinese medicine
protein peptides
polysaccharides
oral absorption
effect form
phase structure
structure-activity relationship
