摘要
动脉粥样硬化是一种以脂质沉积推动、以粥样斑块在动脉壁堆积进而造成动脉狭窄为主要病理过程的一种慢性心血管疾病,是导致患者高死亡率和高致残率的重要因素。粥样斑块的形成发展涉及多种细胞和分子,是机制复杂的慢性退化过程。氧化应激是机体活性氧成分与抗氧化系统之间失衡时引起的一系列的适应性反应,被认为是动脉粥样硬化形成和发展的关键机制之一。本综述将从机体内活性氧的不同来源出发,总结氧化应激与动脉粥样硬化之间的关系,归纳动脉粥样硬化中氧化应激对不同生物分子及生物过程的影响,并简要介绍抗氧化药物在动脉粥样硬化治疗中的研究和应用。
Atherosclerosis is a complicated pathophysiological process characterized by the accumulation of atheromatous plaque in the arterial wall and subsequent narrowing of the arteries,and it is one of the major causes of the high mortality and disability in cardiovascular disease.The initiation and progression of atherosclerosis is a chronic degenerative process with complicated mechanisms involving multiple cells and molecules.Oxidative stress,a series of adaptive responses caused by the imbalance between reactive oxygen species and antioxidant system,is considered as one of the crucial mechanisms in the development of atherosclerosis.This review presents the relationship between oxidative stress and atherosclerosis from the perspective of the different sources of reactive oxygen species in the organism,summarizes the effects of oxidative stress on different cells,biomolecules and biological processes in atherosclerosis,and briefly describes the clinical research and applications of antioxidant agents in the treatment of atherosclerosis.
作者
乔莞宁
陈虹印
张扬
QIAO Wanning;CHEN Hongyin;ZHANG Yang(School of Public Health(Shenzhen),Sun Yat-sen University,Shenzhen,Guangdong 518000,China)
出处
《中国动脉硬化杂志》
CAS
2023年第4期312-321,共10页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金青年项目(82000462)。
关键词
动脉粥样硬化
氧化应激
活性氧
抗氧化治疗
atherosclerosis
oxidative stress
reactive oxygen species
antioxidant therapy
