摘要
目的观察调治天癸方治疗特发性少弱精子症的临床疗效。方法选取2020年6月至2021年6月湖南中医药大学第一附属医院男性病科门诊就诊的80例特发性少弱精子症患者作为研究对象,随机分为调治天癸组和五子衍宗组,每组40例,分别用调治天癸方与五子衍宗软胶囊干预12周,治疗前后观察精液常规、精子DNA碎片指数(DFI)的改善情况及配偶的受孕情况。结果治疗前两组患者的精子密度、前向运动精子率(PR)及DFI均无明显差异。治疗结束后,两组患者精子密度、PR、DFI均较治疗前有所改善(P<0.05),且调治天癸组精子质量及DFI的改善情况优于五子衍宗组(P<0.05)。调治天癸组有7位患者配偶妊娠,总有效率87.50%,五子衍宗组有4位患者配偶妊娠,总有效率67.50%,两组总有效率比较,差异具有统计学意义(P<0.05)。结论调治天癸方可提高特发性少弱精子症患者的精子密度、PR,减少精子DNA碎片化,且无明显不良反应。
Objective To observe the clinical effect of decoction for Tiaozhi Tiangui on idiopathic oligoasthenospermia.Methods A total of 80 patients with idiopathic oligoasthenospermia treated in the Outpatient Department of Andrology of the First Affiliated Hospital of Hunan University of Chinese Medicine from June 2020 to June 2021 were selected as the research objects.They were randomly divided into Tiaozhi Tiangui group and Wuzi Yanzong group,with 40 cases in each group.The patients were treated with Tiaozhi Tiangui prescription and Wuzi Yanzong soft capsule for 12 weeks,respectively.The improvement of semen routine,sperm DNA fragmentation index(DFI)and the fertility of spouses were observed before and after treatment.Results There was no significant difference in sperm density,forward motile sperm percentage(PR)and DFI between the two groups before treatment.After treatment,the sperm density,PR and DFI of the two groups were improved compared with those before treatment(P<0.05),and the improvement of sperm quality and DFI in Tiaozhi Tiangui group was better than that in Wuzi Yanzong group(P<0.05).Seven patients′spouses were pregnant in Tiaozhi Tiangui group,the effective rate was 87.50%,and four patients′spouses were pregnant in Wuzi Yanzong group,the effective rate was 67.50%.The difference between the two groups was statistically significant(P<0.05).Conclusions Decoction for Tiaozhi Tiangui can improve the sperm density and PR of patients with idiopathic oligoasthenospermia,reduce sperm DNA fragmentation,and have no obvious adverse reactions and side effects.
作者
朱文雄
袁轶峰
刘涛
李博
龙柳芽
陈其华
贺菊乔
ZHU Wenxiong;YUAN Yifeng;LIU Tao;LI Bo;LONG Liuya;CHEN Qihua;He Juqiao(Department of Andrology,the First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410007,Hunan,China)
出处
《中国性科学》
2023年第3期126-129,共4页
Chinese Journal of Human Sexuality
基金
湖南省自然科学基金青年基金项目(2022JJ40335)
湖南省中医药科研计划重点指导课题(E2022009)
陈其华全国名老中医药专家传承工作室建设项目
湖南省卫生健康委科研计划课题(B202304058417)
湖南省中医药科研计划课题(B2023096)。
关键词
调治天癸方
少弱精子症
临床观察
Decoction for Tiaozhi Tiangui
Oligoasthenospermia
Clinical observation
