摘要
动脉粥样硬化(atherosclerosis,AS)是心脑血管疾病的共同病理基础,建立具有中医瘀毒证候特色的动脉粥样硬化动物模型及客观规范的评价体系是现代心脑血管疾病研究的重要内容,对中医药防治心脑血管疾病基础研发及药效机制评价具有重要意义。本文通过对动脉粥样硬化瘀毒证的动物模型构建及评价进行了多方面的总结和归纳,同时分析了当前模型构建及评价存在的问题,以期为建立规范化的动物模型提供参考。
Atherosclerosis(AS)is a common pathological basis of cardiovascular and cerebrovascular diseases.Establishing an animal model of AS with the characteristics of blood⁃stasis toxin syndrome and a standardized evaluation system is an important part of modern cardiovascular and cerebrovascular disease research.This model and system are of great significance to research and development of traditional Chinese medicine for the prevention and treatment of cardiovascular and cerebrovascular diseases and the evaluation of drug efficacy mechanisms.This review summarizes and generalizes the construction and evaluation of animal models of atherosclerotic blood⁃stasis and toxic syndrome.The review further analyzes the problems existing with current model construction and evaluation to provide a reference for the establishment of standardized animal models.
作者
张晓囡
吴敏
孙长鑫
陈纪烨
李晓雅
刘龙涛
ZHANG Xiaonan;WU Min;SUN Changxin;CHEN Jiye;LI Xiaoya;LIU Longtao(National Clinical Research Center for Chinese Medicine Cardiology,China Academy of Chinese Medical Sciences,Xiyuan Hospital,Beijing 100091,China;China Academy of Chinese Medical Sciences,Guang’anmen Hospital,Beijing 100053;Beijing University of Chinese Medicine,Beijing 100029)
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2023年第1期98-105,共8页
Acta Laboratorium Animalis Scientia Sinica
基金
国家自然科学基金(81973689,82074254)
北京市自然科学基金(7202176)
首都卫生发展科研专项(2022-2-4172)
国家中医药管理局青年岐黄学者支持项目。
关键词
动脉粥样硬化
瘀毒证
动物模型
病证结合
atherosclerosis
blood⁃stasis and toxin syndrome
animal models
combination of disease and syndrome
