摘要
目的探讨降逆通腑方治疗内脏高敏感脾胃湿热型非糜烂性反流病(NERD)的临床疗效及其对患者胃肠激素的影响。方法选取2020年1月—2021年6月就诊于医院符合纳入标准的脾胃湿热型NERD患者80例,随机均分为对照组和试验组,试验组予以降逆通腑方治疗,对照组予以高仿中药颗粒安慰剂,共治疗8周。观察并比较两组患者的临床疗效、治疗前后中医证候积分,以及生活质量评分、血清胃肠激素以及食管动力变化。结果试验组患者的总有效率为95.00%(38/40),与对照组(80.00%,32/40)比较,试验组明显上调(P<0.05)。治疗8周后,试验组患者的反酸、胸骨后疼痛不适以及反流症状评分相较于对照组显著下调(P<0.01);试验组患者的LESP水平明显上调,而UES水平相较于对照组显著下调(P<0.01)。治疗前两组患者的胃肠激素水平均无显著差异(P>0.05),治疗8周后,试验组患者的外周血中MTL以及GAS水平相较于对照组显著上调(P<0.01);治疗前两组患者的生活质量评分量表各部分评分差异均无统计学意义(P>0.05),治疗8周后,试验组患者的总体健康、生理职能以及情感职能评分均显著上调(P<0.05,P<0.01)。结论降逆通腑方能够提高内脏高敏感脾胃湿热型NERD患者的临床疗效,改善患者症状,并可改善食管动力、调节胃肠激素,且未见不良反应增加。
Objective To observe the effect of Jiangni Tongfu Recipe(降逆通腑方)on patients with visceral hypersensitive non-erosive reflux disease(NERD)of damp-heat in spleen and stomach syndrome and its effect on gastrointestinal hormones.Methods A total of 80 NERD patients with damp-heat in spleen and stomach syndrome admitted to the hospital from January 2020 to June 2021 meeting inclusion criteria were selected and randomly divided into control group and experimental group.The experimental group was treated with self-designed Jiangni Tongfu Recipe and the control group was treated with high imitation Chinese medicine granule placebo for 8 weeks.The clinical efficacy,TCM syndrome score before and after treatment,quality of life score,serum gastrointestinal hormone and esophageal dynamic changes were observed and compared between two groups.Results The total effective rate of the experimental group was 95.00%(38/40),which was significantly increased compared with that of the control group(80.00%,32/40)(P<0.05).After 8 weeks of treatment,the scores of acid reflux,retrosternal pain and discomfort and reflux symptoms in the experimental group were significantly decreased compared with those of the control group(P<0.01).Lower esophageal sphincter pressure(LESP)level in the experimental group was significantly up-regulated,while upper esophageal sphincter(UES)level was significantly down-regulated compared with those of the control group(P<0.01).There were no significant differences in gastrointestinal hormone levels between the two groups before treatment(P>0.05).After 8 weeks of treatment,the levels of motilin(MTL)and gastrin(GAS)in peripheral blood of the experimental group were significantly increased compared with those of the control group(P<0.01).Before treatment,there was no significant difference in the scores of all parts of Quality of Life Rating Scale between the two groups(P>0.05).After treatment for 8 weeks,the scores of overall health,physiological function and emotional function of the experimental group were significantly increased(P<0.05,P<0.01).Conclusion Jiangni Tongfu Recipe can improve the clinical efficacy and symptoms of patients with NERD of damp-heat in spleen and stomach syndrome,improve esophageal motility and regulate gastrointestinal hormones,with no increase in adverse reactions.
作者
张丽娜
郭洪波
李佩芳
ZHANG Lina;GUO Hongbo;LI Peifang(The First Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi,China;The Affiliated Hospital of Shanxi University of Chinese Medicine,Taiyuan 030024,Shanxi,China)
出处
《中华中医药学刊》
CAS
北大核心
2023年第3期194-197,共4页
Chinese Archives of Traditional Chinese Medicine
基金
山西省中医药管理局项目(2020ZYYZ019)。
关键词
降逆通腑方
非糜烂性反流病
脾胃湿热型
胃肠激素
临床疗效
Jiangni Tongfu Recipe(降逆通腑方)
non-erosive reflux disease
damp-heat in spleen and stomach syndrome
gastrointestinal hormones
clinical efficacy
