摘要
目的观察沟通表里和解祛邪法治疗斑块状银屑病对患者皮损面积、血液流变学、血清γ-干扰素(IFN-γ)、白细胞介素(IL)-2及IL-10水平的影响。方法选取2020年2月—2020年10月医院诊治的斑块状银屑病患者82例作为研究对象,按照随机数字表法均分为两组,每组41例,对照组采用司库奇尤单抗治疗,观察组在对照组基础上增加沟通表里和解祛邪法治疗。比较两组患者的临床疗效,皮损面积,血液流变学,血清IFN-γ、IL-2及IL-10水平,不良反应发生情况。结果观察组愈显率为70.7%(29/41),显著高于对照组的48.8%(20/41),组间差异有统计学意义(P<0.05),但两组总有效率比较差异无统计学意义(P>0.05)。治疗前两组患者皮损面积及严重程度指数(PASI)评分比较差异无统计学意义(P>0.05),治疗后12周两组PASI评分均显著降低,并且观察组显著低于对照组(P<0.05)。治疗前两组患者的高切及低切全血黏度、血浆黏度、红细胞压积、红细胞聚集指数差异均无统计学意义(P>0.05),治疗后12周两组各指标均显著改善,并且观察组以上各指标均显著低于对照组(P<0.05)。治疗前两组患者的血清IFN-γ、IL-2及IL-10水平差异均无统计学意义(P>0.05),治疗后12周两组各指标均显著改善,并且观察组血清IL-2及IL-10水平均显著低于对照组(P<0.05),组间血清IFN-γ水平差异无统计学意义(P>0.05)。观察组、对照组不良反应发生率分别为7.3%(3/41)、9.8%(4/41),差异无统计学意义(P>0.05)。结论沟通表里和解祛邪法治疗斑块状银屑病效果满意,能够更好地消退皮损,改善血液流变学及炎性因子水平,是安全、有效的治疗方案。
Objective To study the effects of reconciling the exterior and the interior and eliminating evils therapy on lesion area,hemorheology,serumγ-interferon(IFN-γ),interleukin(IL)-2 and IL-10 in patients with plaque psoriasis.Methods Eighty-two patients with plaque psoriasis diagnosed and treated in the hospital from February to October 2020 were selected and divided into two groups according to the random number table method,with 41 cases in each group.The control group was treated with Scuqiyu monoclonal antibody,and the observation group was treated with reconciling the exterior and the interior and eliminating evils on the basis of the control group.The clinical efficacy,lesion area,hemorheology,serum levels of IFN-γ,IL-2 and IL-10 and incidence of adverse reactions were compared between two groups.Results The effective rate in the observation group was 70.7%(29/41),which was significantly higher than 48.8%(20/41)in the control group,and the difference between the two groups was statistically significant(P<0.05),but there was no significant difference in the total effective rate between the two groups(P>0.05).Before treatment,there was no significant difference in the lesion area or severity index(PASI)scores between the two groups(P>0.05),12 weeks after treatment,the PASI scores of two groups were significantly decreased,and the scores of the observation group were significantly lower than those of the control group(P<0.05).There was no significant difference in whole blood viscosity,plasma viscosity,hematocrit or erythrocyte aggregation index between two groups before treatment(P>0.05).12 weeks after treatment,the indexes in two groups were significantly improved,and the above indexes in the observation group were significantly lower than those in the control group(P<0.05).There was no significant difference in serum IFN-γ,IL-2 or IL-10 between two groups before treatment(P>0.05).After 12 weeks of treatment,the indexes in two groups were significantly improved,and the serum levels of IL-2 and IL-10 in the observation group were significantly lower than those in the control group(P<0.05).There was no significant difference in serum IFN-γlevel between two groups(P>0.05).The incidence rates of adverse reactions in the observation group and control group were 7.3%and 9.8%,respectively,and the difference was not statistically significant(P>0.05).Conclusion Reconciling the exterior and the interior and eliminating evils in the treatment of psoriasis has satisfactory effect.It can better subside the skin lesions and improve the levels of hemorheology and inflammatory factors and is a safe and effective treatment plan.
作者
沈丹丹
王希
喻治达
SHEN Dandan;WANG Xi;YU Zhida(Affiliated Hospital of Jiangxi University of Chinese Medicine,Nanchang 330006,Jiangxi,China;Dermatology Hospital of Jiangxi Province,Nanchang 330001,Jiangxi,China;School of Physical Education and Health,Jiangxi University of Chinese Medicine,Nanchang 330006,Jiangxi,China)
出处
《中华中医药学刊》
CAS
北大核心
2023年第3期212-215,共4页
Chinese Archives of Traditional Chinese Medicine
基金
江西省卫生计生委员会中医药项目(2018A137)。
关键词
斑块状银屑病
表里双解
祛邪法
皮损面积
血液流变学
γ-干扰素
白细胞介素
plaque psoriasis
reconciling the exterior and the interior
eliminating evils
skin lesion area
hemorheology
γ-interferon
interleukin
