摘要
目的探究支气管哮喘急性发作期患者血清免疫球蛋白E(immunoglobulin E,IgE)与超敏C反应蛋白(high-sensitivity C-reactive protein,hsCRP)的水平变化及临床意义。方法回顾性分析2019年9月至2021年12月延安大学咸阳医院152例支气管哮喘患者临床资料,根据入院时喘息控制状态分为急性发作组88例与临床缓解组64例,另选取同期健康体检者50例为对照组。检测血清IgE与hsCRP水平及肺功能指标[用力肺活量(forced vital capacity,FVC)、第1s用力呼气容积(forced expiratory volume in one second,FEV1)及1秒率(FEV1/FVC%)],采用Pearson相关分析法分析血清IgE、hsCRP与肺功能指标的相关性,绘制受试者工作特征曲线(receiver operator characteristic curve,ROC曲线),分析血清IgE与hsCRP对支气管哮喘急性发作的诊断价值。结果急性发作组血清IgE与hsCRP水平均高于临床缓解组与对照组(P<0.05),肺功能指标均低于临床缓解组与对照组(P<0.05);不同严重程度患者血清IgE、hsCRP水平为重度组>中度组>轻度组(P<0.05),肺功能指标为重度组<中度组<轻度组(P<0.05);Pearson相关分析显示,血清IgE与FVC、FEV1、FEV1/FVC均呈负相关(P<0.05),hsCRP与FEV1、FEV1/FVC均呈负相关(P<0.05);血清IgE与hsCRP诊断支气管哮喘急性发作的ROC曲线下面积分别为0.843、0.807(P<0.05)。结论支气管哮喘急性发作期患者血清IgE与hsCRP表达水平明显升高,且与患者肺功能下降有相关性,检测血清IgE与hsCRP水平对支气管哮喘急性发作临床诊断有一定的价值。
Objective To explore the changes and clinical significance of serum immunoglobulin E(IgE)and highsensitivity C-reactive protein(hsCRP)levels in patients with acute exacerbation of bronchial asthma.Methods The clinical data of 152 patients with bronchial asthma in Xianyang Hospital of Yan′an University were retrospectively analyzed between September 2019 and December 2021.According to the wheezing control status at admission,the patients were divided into acute exacerbation group(88 cases)and clinical remission group(64 cases).Another 50 healthy subjects with physical examination during the same time period were included in control group.The levels of serum IgE and hsCRP and pulmonary function indicators[forced vital capacity(FVC),forced expiratory volume in 1 s(FEV1),and 1 second rate(FEV1/FVC%)]were detected.Pearson correlation analysis was used to analyze the correlation between serum IgE,hsCRP and pulmonary function indicators,and receiver operator characteristic curve(ROC curve)was used to explore the diagnostic value of serum IgE and hsCRP on acute exacerbation of bronchial asthma.Results Serum IgE and hsCRP in acute exacerbation group were higher than those in clinical remission group and control group(P<0.05),while the pulmonary function indicators were lower than those in clinical remission group and control group(P<0.05).Serum IgE and hsCRP levels in patients with different severity status were shown as severe group>moderate group>mild group(P<0.05),while pulmonary function indicators showed severe group<moderate group<mild group(P<0.05).Pearson correlation analysis showed that serum IgE was negatively correlated with FVC,FEV1 and FEV1/FVC(P<0.05),and hsCRP was negatively correlated with FEV1 and FEV1/FVC(P<0.05).The areas under the ROC curves of serum IgE and hsCRP in the diagnosis of acute exacerbation of bronchial asthma were 0.843 and 0.807 respectively(P<0.05).Conclusion The expression levels of serum IgE and hsCRP in patients with acute exacerbation of bronchial asthma are significantly increased,and they are correlated with the decline of pulmonary function in patients.Detection of serum IgE and hsCRP levels has certain value in the clinical diagnosis of acute exacerbation of bronchial asthma.
作者
刘丹丹
张森
LIU Dandan;ZHANG Sen(Xianyang Hospital of Yan′an University,Xianyang 712000,China)
出处
《延安大学学报（医学科学版）》
2023年第1期63-66,73,共5页
Journal of Yan'an University:Medical Science Edition
关键词
支气管哮喘
急性发作
免疫球蛋白E
超敏C反应蛋白
肺功能
Bronchial asthma
Acute exacerbation
Immunoglobulin E
High-sensitivity C-reactive protein
Pulmonary function
