摘要
胰腺外分泌功能不全是指由于各种原因引发的胰酶分泌不足或胰酶分泌不同步,从而导致患者出现消化吸收不良等症状。肠道菌群是肠黏膜表面数量庞大的微生物群落,主要功能包括肠道免疫功能、构成肠道生物屏障以及参与营养与代谢的调节等。由于衰老,部分老年人常会出现不明原因的慢性胰腺功能不全,常表现为不明原因的体重下降和营养不良。多项研究表明,肠道微生物组的组成随着年龄的增长发生显著变化。本文围绕衰老及其相关胰腺外分泌功能不全和可能对肠道菌群的影响做一综述,为针对老年人胰腺外分泌功能改变及菌群变化特征制定个体化防治策略提供参考依据。
Pancreatic exocrine insufficiency(PEI)refers to insufficient or non-synchronous secretion of trypsin caused by various reasons,resulting in dyspepsia and other symptoms.Intestinal microbiota is a large number of microbiota on the surface of intestinal mucosa.Its main functions include intestinal immune function,forming intestinal biological barrier and participating in the regulation of nutrition and metabolism.Due to aging,some elderly people often have unexplained chronic pancreatic insufficiency,which is often characterized by unexplained weight loss and malnutrition.Several studies have shown that the composition of intestinal microbiota changes significantly with age.This article focuses on aging and its related PEI and then reviews its possible effects on intestinal microbiota,in order to provide a reference basis for individualized prevention and treatment strategies according to the changes of pancreatic exocrine function and microbiota in the elderly.
作者
蒋哲
郭玉霖
王硕
曹锋
李非
Jiang Zhe;Guo Yulin;Wang Shuo;Cao Feng;Li Fei(Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2023年第3期237-240,共4页
Chinese Journal of Hepatobiliary Surgery
基金
北京高校高精尖学科建设项目(1192070312)。
关键词
胰腺外分泌功能不全
衰老
胃肠道微生物组
Exocrine pancreatic insufficiency
Aging
Gastrointestinal microbiome
