摘要
目的调查非职业性成人血铅水平及其分布特点,分析血铅超标的影响因素和其与高血压患病情况的关系。方法采用石墨炉原子吸收光谱法检测血铅浓度,同时采用问卷调查的方式收集影响血铅水平的潜在因素和高血压的患病情况。采用秩和检验、卡方检验、Logistic回归,限制性立方样条(restrictive cubic spline,RCS)的Logistic回归模型的方法分析血铅超标的影响因素和其与高血压患病的关系。结果非职业性成人血铅含量中位数和四分位间距(M±Q)为(0.031±0.020)mg/L,血铅超标率为13.07%。单因素Logistic回归分析结果显示:非职业性成人年龄>60岁比年龄≤60岁血铅超标的概率降低88%(P<0.05);饮酒比不饮酒的血铅超标的概率增加3.014倍(P<0.05);血铅超标将导致高血压的患病率增加2.87倍(P<0.05);限制性立方样条模型结合多因素Logistic回归分析结果显示:血铅超标将会导致高血压发生的概率增加7.66倍(P<0.05),当血铅值≥0.031 mg/L,血铅常用对数值(lgpb)与高血压间存在明显的非线性剂量-反应关系(整体关联性检验χ2=10.26,P=0.001,非线性检验χ2=8.87,P=0.012),并随血铅含量的增加,高血压患病率呈明显上升趋势。结论非职业性成人血铅水平超标将增加高血压的患病率,高危人群应定期体检,加强对铅超标高危因素的认识,减少接触,减轻血铅超标的损害。
Objective To investigate the blood lead level and its distribution in non-occupational adults,and to analyze the association of excessive blood lead with hypertension.Methods The concentration of lead in blood was detected by GFAAS,and the potential factors affecting blood lead level and the prevalence of hypertension were collected by questionnaire.Rank sum test,chi-square test,Logistic regression,and the restrictive Cubic Spline(RCS)of Logistic regression were used to analyze the influencing factors of excess lead in blood and its association with hypertension.Results The median and quartile spacing(M±Q)of blood lead levels in non-occupational adults was(0.031±0.020)mg/L,and the blood lead exceedance rate was 13.07%.The results of univariate logistic regression analysis showed that the probability of excessive blood lead in non-occupational adults aged>60 years was 88%lower than that in those aged≤60 years(P<0.05);the probability of excessiveblood lead in alcohol consumption was 3.014 times higher than that in non-alcohol consumption(P<0.05);and excessive blood lead would lead to 2.87 times higher prevalence of hypertension(P<0.05).Restricted cubic spline model combined with the multi-factor logistic regression analysis results show that the incidence of blood lead levels will increase the probability of hypertension by 7.66 times.When the blood lead level was≥0.031 mg/L,there was a significant nonlinear dose-response relationship between the common logarithm of blood lead(lgpb)and hypertension(global correlation testχ2=10.26,P=0.001,nonlinear testχ2=8.87,P=0.012),and the prevalence of hypertension showed a significant increase with the increase of blood lead content.Conclusion Ex�cessive blood lead level in non-occupational adults will increase the prevalence of hypertension.High risk groups should have regular physical examination,strengthen the understanding of high risk factors of excessive lead,reduce exposure,and reduce the damage of excessive blood lead.
作者
王秀芳
施红伶
周文刚
刘天云
朱为梅
冯艳慧
陈科容
周盛
WANG Xiufang;SHI Hongling;ZHOU Wengang;LIU Tianyun;ZHU Weimei;FENG Yanhui;CHEN Kerong;ZHOU Sheng(Dept.of Medical Records and Statistics,The 3rd People’s Hospital of Yunnan Province,Kunming Yunnan 650011,China;Dept.of Rehabilitation Medicine,The 3rd People’s Hospital of Yunnan Province,Kunming Yunnan 650011,China;Dept.of Medical Administration,The 3rd People’s Hospital of Yunnan Province,Kunming Yunnan 650011,China;Dept.of Nursing,The 3rd People’s Hospital of Yunnan Province,Kunming Yunnan 650011,China;Dept.of Occupational Medicine,The 3rd People’s Hospital of Yunnan Province,Kunming Yunnan 650011,China)
出处
《昆明医科大学学报》
CAS
2023年第4期106-111,共6页
Journal of Kunming Medical University
基金
云南省医疗卫生单位内设研究机构科研基金资助项目(2016NS334)。
