摘要
目的 分析中医院外科住院患者伤口分泌物病原菌及药敏试验,为控制院内感染提供参考。方法 选择62位外科住院患者分泌物样本74份,分析其病原菌分布及耐药性情况。结果 共有菌株104株,其中革兰阴性菌(Gram negative bacteria,G^(-))80株,以大肠埃希菌(22.12%)、铜绿假单胞菌(17.31%)、奇异变形杆菌(11.54%)和肺炎克雷伯氏菌肺炎亚种(9.62%)为主;革兰阳性菌(Gram positive bacteria,G^(+))22株,以金黄色葡萄球菌(14.42%)、凝固酶阴性葡萄球菌(2.88%)为主;真菌2株,均为白色假丝酵母菌(1.92%)。大肠埃希菌对哌拉西林、氨苄西林具有较高耐药性(>65%),对阿米卡星、多黏菌素E耐药性低;铜绿假单胞菌对阿米卡星耐药性低;奇异变形杆菌对哌拉西林/他唑巴坦、美洛培南、阿米卡星和阿莫西林/克拉维酸耐药性低;肺炎克雷伯氏菌肺炎亚种对多黏菌素E耐药性低;金黄色葡萄球菌对氨苄西林、红霉素耐药性较高(>50%),对万古霉素、利奈唑胺等耐药性低;白色假丝酵母菌对5-氟胞嘧啶、二性霉素B等耐药性低。结论 该中医院外科住院患者伤口分泌物病原菌以G^(-)菌为主,多种病原菌对临床常用药物表现出较高的耐药性。
Objective To analyze pathogens of wound secretions and drug sensitivity test for surgical inpatients of a traditional Chinese medicine(TCM)hospital so as to provide reference for controlling nosocomial infection.Methods A total of 74 secretion samples from 62 surgical inpatients were collected.The distribution and drug resistance of pathogens were analyzed.Results There were 104 strains of pathogens,including 80 strains of Gram negative bacteria(G-),[mainly including Escherichia coli(22.12%),Pseudomonas aeruginosa(17.31%),Proteus mirabilis(11.54%)and Klebsiella pneumoniae(9.62%)],22 strains of Gram positive bacteria(G+)[mainly including Staphylococcus aureus(14.42%)and coagulase negative Staphylococci(2.88%)]and 2 strains of fungi[Candida albicans(1.92%)].The resistance of Escherichia coli was high to piperacillin and ampicillin(>65%),but low to amikacin and polymyxin E.The resistance of Pseudomonas aeruginosa was low to amikacin.The resistance of Proteus mirabilis was low to piperacillin/tazobactam,meropenem,amikacin and amoxicillin/clavulanic acid.The resistance of Klebsiella pneumoniae ssp pneumoniae was low to polymyxin E.The resistance of Staphylococcus aureus was high to ampicillin and erythromycin(>50%),but low to vancomycin and linezolid.The resistance of Candida albicans was low to 5-flucytosine and amphotericin B.Conclusion The main pathogen in wound secretions is G-bacteria in surgical inpatients in the TCM hospital.There is high resistance of different pathogens to commonly used drugs.
作者
尹莉
李霞
刘翔
高翔
YIN Li;LI Xia;LIU Xiang;GAO Xiang(Department of Laboratory Medicine,the Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230000,China;Department of Surgery,the Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230000,China)
出处
《西北药学杂志》
CAS
2023年第3期196-199,共4页
Northwest Pharmaceutical Journal
基金
安徽高等学校自然科学基金项目(编号:KJ2020A0406)。
关键词
药敏试验
病原菌
外科
住院病人
伤口分泌物
drug sensitivity test
pathogen
surgery
inpatient
wound secretion
