摘要
目的探究血清血小板活化因子结合ABCD3-Ⅰ评分预测老年短暂性脑缺血发作(TIA)后进展为脑梗死的价值。方法回顾性选择2020年6月至2022年6月来保定市第二医院治疗的260例老年TIA患者进行研究。患者发病第2天进行临床检查及检验。将入院7 d内进展为脑梗死的50例患者作为观察组,未进展为脑梗死的210例患者作为对照组。分析比较2组患者血清血小板活化因子(PAF)水平、ABCD3-Ⅰ评分。统计比较TIA患者ABCD3-Ⅰ评分分层与患者进展为脑梗死的发生率。比较观察组患者TIA不同持续时间血清PAF水平、ABCD3-Ⅰ评分。采用ROC曲线分析PAF联合ABCD3-Ⅰ评分评价TIA后进展为脑梗死的价值。结果观察组患者的血清PAF水平、ABCD3-Ⅰ评分均显著高于对照组(P<0.01)。TIA患者ABCD3-Ⅰ评分分层低危组、中危组、高危组脑梗死发生率为0.00%、8.87%、33.91%(P<0.05)。观察组患者TIA持续时间越长血清PAF水平、ABCD3-Ⅰ评分越高(P<0.05)。PAF水平、ABCD3-Ⅰ评分、PAF水平联合ABCD3-Ⅰ评分评价患者发生脑梗死曲线下面积分别为0.799、0.784、0.841;敏感性分别为70.2%、68.1%、85.6%;特异性分别为57.4%、72.1%、80.9%(P<0.01)。PAF水平联合ABCD3-Ⅰ评分评价患者发生脑梗死曲线下面积显著高于2个指标单独预测(P<0.05)。结论血清PAF结合ABCD3-Ⅰ评分对老年TIA后进展为脑梗死有一定的预测价值。
Objective To explore the value of serum platelet activating factor(PAF)combined with ABCD3-Ⅰscore in predicting the progression of senile transient cerebral ischemia(TIA)to cerebral infarction.Methods A total of 260elderly TIA patients admitted in our hospital from June 2020to June 2022were selected retrospectively.All of them patient received clinical and laboratory examinations on the second day of onset.Within 7dafter admission,50of them who progressed to cerebral infarction were assigned into the observation group,and the other 210who did not into the control group.The serum PAF level and ABCD3-Ⅰscore were analyzed and compared between the two groups.After the TIA patients were stratified with the ABCD3-Ⅰscore,the incidence of cerebral infarction were statistically analyzed in different score groups.The serum PAF level and ABCD3-Ⅰscore were compared in the patients with TIA in different duration.ROC curve was drawn to analyze the value of PAF combined with ABCD3-Ⅰscore in evaluating the progression of cerebral infarction after TIA onset.Results The serum PAF level and ABCD3-Ⅰscore were significantly higher in the observation group than the control group(t=26.151,6.768,P<0.05).The incidence of cerebral infarction were 0.00%,8.87%and 33.91%,respectively in low,medium and high ABCD3-Ⅰscore groups(P<0.05).In the observation group,the patients with longer duration of TIA had higher serum PAF level and ABCD3-Ⅰscore(P<0.05).The AUC value of PAF level,ABCD3-Ⅰscore and their combination in evaluating the progression of cerebral infarction was 0.799,0.784and 0.841respectively,with a sensitivity of 70.2%,68.1%and 85.6%,and a specificity of 57.4%,72.1%and 80.9%,respectively(P<0.01).The AUC value of combined two indicators was statistically higher than them alone(P<0.05).Conclusion Serum PAF level combined with ABCD3-Ⅰscore has a certain predictive value for progression of cerebral infarction in the elderly after the onset of TIA.
作者
黄丽
王磊
吴亚琴
王丽
Huang Li;Wang Lei;Wu Yaqin;Wang Li(Second Department of Neurology,Baoding Second Hospital,Baoding071000,Hebei Province,China)
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2023年第4期399-403,共5页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
保定市科技计划项目(1951ZF019)。
