摘要
目的 探究轻微型肝性脑病(minimal hepatic encephalopathy, MHE)患者区域神经活动的异常动态特征,并评估改变的动态区域指数是否与MHE患者的临床行为相关。材料与方法 本研究共纳入25名健康志愿者(对照组)和28名MHE患者,均进行静息态功能磁共振成像、数字连接试验A(number connection test A, NCT-A)、数字符号试验(digit symbol test,DST)及蒙特利尔认知评估量表(Montreal Cognitive Assessment, MoCA)评分,利用滑动时间窗计算动态局部一致性(dynamic regional homogeneity, dReHo)的时间变异性,以评估MHE患者脑区局部一致性(regional homogeneity, ReHo)的时间动态特性。使用Pearson相关分析法分别对dReHo的变异性和NCT-A、DST及MoCA评分之间的相关性进行分析。结果 对照组与MHE组的NCT-A(t=-7.906,P<0.01)、DST(t=9.380,P<0.01)及MoCA(t=7.508,P<0.01)评分之间均存在显著差异。MHE组与对照组相比左侧额中回、左侧额下回、左侧苍白球、左侧海马、右侧额中回以及右侧颞下回的dReHo值升高,MHE组dReHo显著高于对照组(高斯随机场校正,P<0.05)。相关分析显示MoCA评分与差异脑区右侧额中回dReHo值呈负相关(r=-0.50,P<0.05),与右侧颞下回呈正相关(r=0.70,P<0.05)。结论 MHE患者内在大脑活动变异性模式发生了改变,dReHo变异性在理解MHE神经生理机制及其诊断方面具有潜在的价值。
Objective:This study attempted to investigate the abnormal dynamic characteristics of regional neural activity in minimal hepatic encephalopathy(MHE)patients and to assess whether altered dynamic regional indices are associated with clinical behavior in MHE patients.Materials and Methods:A total of 25 healthy volunteers(the control group)and 28 MHE patients were enrolled in this study,followed by resting-stated functional magnetic resonance imaging and number connection test A(NCT-A),digit symbol test(DST),Montreal Cognitive Assessment(MoCA)scale.A sliding time window was used to calculate the temporal variability of dynamic regional homogeneity(dReHo)to assess the temporal dynamics of the dReHo in MHE.Using Pearson correlation.The correlations between the variability of dReHo and NCT-A,DST,MoCA were performed.Results:Between the control group and the MHE group,the NCT-A(t=-7.906,P<0.01),DST(t=9.380,P<0.01)and MoCA(t=7.508,P<0.01)scale scores were significantly different.The left middle frontal gyrus,left inferior frontal gyrus,left globus pallidus,left hippocampus,right middle frontal gyrus and right inferior temporal gyrus were significantly different in the MHE group compared with the control group.The dReHo were higher in the MHE group than in the control group(Gaussian random field corrected,P<0.05).Correlation analysis showed that MoCA scale scores were negatively correlated with dReHo values in the right middle frontal gyrus(r=-0.50,P<0.05),and positively correlated with the right inferior temporal gyrus(r=0.70,P<0.05).Conclusions:The intrinsic brain activity variability pattern of MHE patients changed,dReHo has potential value in understanding the neurophysiological mechanisms of MHE and its diagnosis.
作者
郑佳瑞
王明磊
杨旭宏
马万龙
刘珊
马文富
丁向春
王晓东
ZHENG Jiarui;WANG Minglei;YANG Xuhong;MA Wanlong;LIU Shan;MA Wenfu;DING Xiangchun;WANG Xiaodong(Ningxia Medical University School of Clinical Medicine,Yinchuan 750004,China;Department of Radiology,General Hospital of Ningxia Medical University,Yinchuan 750004,China;Department of Infectious Diseases,General Hospital of Ningxia Medical University,Yinchuan 750004,China;Key Laboratory of Craniocerebral Diseases of Ningxia Medical University,Yinchuan 750004,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2023年第4期6-10,40,共6页
Chinese Journal of Magnetic Resonance Imaging
基金
宁夏回族自治区自然科学基金(编号:2022AAC03487)
宁夏回族自治区科技重点研发计划(编号:2019BEG03037)。
关键词
轻微型肝性脑病
静息态功能磁共振成像
磁共振成像
认知功能
动态局部一致性
神经活动
minimal hepatic encephalopathy
resting-state functional magnetic resonance imaging
magnetic resonance imaging
cognitive function
dynamic regional homogeneity
nerve activity
