摘要
目的探讨消核通窍方治疗痰瘀互结型小儿腺样体肥大的临床效果。方法选取2021年1月至12月河南省中医院痰瘀互结型小儿腺样体肥大的77例患儿,按照随机数字表法分为治疗组(39例)、对照组(38例)。治疗组予消核通窍方,对照组予糠酸莫米松鼻喷雾剂联合孟鲁司特钠咀嚼片。治疗4周后,比较两组临床疗效、中医证候积分、生活质量、腺样体体积A/N值积分、白细胞介素(IL)-4、IL-6、嗜酸性粒细胞百分比(EOS%)及血清总免疫球蛋白E(IgE)变化,观察两组不良反应及复发率。结果治疗组临床疗效优于对照组(P<0.05)。治疗后,两组夜眠打鼾、张口呼吸、鼻塞、咳嗽咳痰、咽痛、恶心纳呆、头身困重、憋气憋醒、面色积分均低于治疗前,且治疗组低于对照组(P<0.05)。治疗后,两组OSA-18量表评分低于治疗前,且治疗组低于对照组(P<0.05)。治疗后,两组A/N值积分较治疗前降低,且治疗组低于对照组(P<0.05)。治疗后,两组IL-4、IL-6水平低于治疗前,且治疗组低于对照组(P<0.05)。治疗后,两组EOS%及血清总IgE低于治疗前,且治疗组EOS%低于对照组(P<0.05)。两组治疗期间均未出现明显不良反应。治疗组复发率低于对照组(P<0.05)。结论消核通窍方治疗痰瘀互结型小儿腺样体肥大效果显著。
Objective To explore the clinical effect of Xiaohe Tongqiao Prescription on adenoid hypertrophy of phlegm-stasis interjunction type in children.Methods A total of 77 adenoid hypertrophy with phlegm-stasis interjunction type in Henan Provincial Hospital of Traditional Chinese Medicine from January to December 2021 were selected,they were divided into treatment group(39 cases)and control group(38 cases)according to the random number table method.The treatment group was given Xiaohe Tongqiao Prescription,and the control group was given Mometasone Furoate Nasal Spray and Montelukast Sodium Chewable Tablet.After four weeks,the clinical efficacy,traditional Chinese medicine syndrome score,quality-of-life,adenoid volume A/N score,interleukin(IL)-4,IL-6,eosinophilic percentage(EOS%),and serum total immunoglobulin E(IgE)between two groups were compared,and adverse reactions and recurrence rates between two groups were observed.Results The clinical effect of treatment group was better than that of control group(P<0.05).After treatment,the scores of night sleep snoring,open mouth breathing,nasal congestion,cough and sputum,sore throat,nausea,head and body sleepiness,breathing and awakening,and face of two groups were lower than those before treatment,and treatment group was lower than control group(P<0.05).After treatment,the scores of the OSA-18 scale in both groups were lower than those before treatment,and the treatment group was lower than the control group(P<0.05).After treatment,the scores of A/N of two groups were lower than those before treatment,and treatment group was lower than control group(P<0.05).After treatment,the levels of IL-4 and IL-6 in both groups were lower than those before treatment,and treatment group was lower than control group(P<0.05).After treatment,EOS%and serum total IgE in both groups were lower than those before treatment,and EOS%in treatment group was lower than that in control group(P<0.05).Conclusion Xiaohe Tongqiao Prescription has remarkable effect on adenoid hypertrophy of phlegm-stasis interjunction type in children.
作者
乔淑楠
朱珊
张娅
李新阳
QIAO Shunan;ZHU Shan;ZHANG Ya;LI Xinyang(Medicial College of Pediatrics,Henan University of Chinese Medicine,Henan Province,Zhengzhou450000,China;Department of Pediatrics,Henan Provincial Hospital of Traditional Chinese Medicine,Henan Province,Zhengzhou450000,China)
出处
《中国医药导报》
CAS
2023年第11期89-93,共5页
China Medical Herald
基金
河南省中医药科学研究专项课题(2022ZY1072)
河南省高等学校重点科研项目(19A360005)。
关键词
腺样体肥大
痰瘀互结型
消核通窍方
临床效果
Adenoid hypertrophy
Phlegm-stasis interjunction type
Xiaohe Tongqiao Prescription
Clinical effect
