摘要
目的讨论临床药师在促进肿瘤患者合理使用质子泵抑制剂方面的作用。方法选取临床药师干预前使用质子泵抑制剂的住院病例(2019年9月至12月)及干预后使用质子泵抑制剂的住院病例(2020年1月和4月至6月)各360例,比较临床药师干预前后质子泵抑制剂的不合理使用情况,包括无适应证用药、用法用量不适宜、超疗程用药、特殊人群用药未及时调整等。结果经药师干预,我院肿瘤患者质子泵抑制剂静脉制剂使用率显著降低(P<0.05),不合理使用率由76.39%下降至42.22%,干预效果显著;其中在抗肿瘤治疗前使用质子泵抑制剂预防消化道反应的不合理用药现象得到了明显改善(34.72%vs.23.33%,P<0.05)。结论临床药师促进了质子泵抑制剂在肿瘤患者中的合理使用。
Objective To discuss the importance of clinical pharmacists in promoting rational use of proton pump inhibi-tor in cancer patients.Methods Medical records of 360 inpatients using proton pump inhibitor before intervention(from September to December in 2019)and another 360 inpatients using proton pump inhibitor after intervention(January and from April to June in 2020)were selected.The irrational use of proton pump inhibitor before and after intervention by clini-cal pharmacists were compared,including the use of drugs without indication,inappropriate dosage,over-course medica-tion and unadjusted use of drugs in special population.Results After the intervention of pharmacists,the intravenous use rate of proton pump inhibitor in tumor patients in our hospital decreased significantly(P<0.05),and the unreasonable use rate decreased from 76.39%to 42.22%.The irrational use of proton pump inhibitor to prevent gastrointestinal reactions be-fore antitumor treatment was significantly improved(34.72%vs.23.33%,P<0.05).Conclusion Clinical pharmacists had promoted the rational use of proton pump inhibitor in cancer patients.
作者
左靖
夏铮铮
李安娜
唐浩淳
李超
王婷
孟珺
方思贤
ZUO Jing;XIA Zhengzheng;LI Anna;TANG Haochun;LI Chao;WANG Ting;MENG Jun;FANG Sixian(Department of Pharmacy,National Cancer Center/National Clinical Research Center for Cancer/Shenzhen Center,Cancer Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College,Shenzhen,518116,Guangdong,China;School of Pharmacy,Guangdong Medical University,Guangzhou,510089,Guangdong,China)
出处
《肿瘤药学》
CAS
2023年第2期247-254,共8页
Anti-Tumor Pharmacy
基金
中国医学科学院肿瘤医院深圳医院青年启动基金项目(E010321017)
基于微信平台的肿瘤药事服务系统的设计与构建(B20325DS)
深圳市高水平医院建设专项经费。
关键词
临床药师
质子泵抑制剂
肿瘤
合理用药
Clinical pharmacists
Proton pump inhibitor
Cancer
Rational use of drugs
