摘要
目的探讨基质金属蛋白酶抑制剂-1(TIMP-1)、基质金属蛋白酶9(MMP-9)、白细胞介素-6(IL-6)、降钙素原(PCT)在重症肺炎患儿中的变化及与肺功能关系。方法选取该院2019年1月至2022年1月收治的80例肺炎患儿,按照病情严重程度分为重症组(38例)和轻症组(42例),另选取同期健康体检儿童40例作为对照组。比较3组血清TIMP-1、MMP-9、IL-6、PCT水平和肺功能指标最大呼气峰值流速(PEF)、用力肺活量(FVC)、第1秒用力呼气量(FEV 1),分析血清TIMP-1、MMP-9、IL-6、PCT水平与肺功能指标的相关性,分析血清TIMP-1、MMP-9、IL-6、PCT单独及联合检测对重症肺炎的诊断价值。结果重症组TIMP-1、MMP-9、IL-6、PCT水平均高于轻症组和对照组(P<0.05),轻症组高于对照组(P<0.05);重症组PEF、FVC、FEV 1水平低于轻症组和对照组(P<0.05),轻症组低于对照组(P<0.05)。Pearson相关分析结果显示,重症组和轻症组TIMP-1、MMP-9、IL-6、PCT与PEF、FVC、FEV 1均呈负相关(P<0.05);血清TIMP-1、MMP-9、IL-6、PCT 4项指标联合检测诊断重症肺炎的曲线下面积高于单项检测(P<0.05)。结论TIMP-1、MMP-9、IL-6、PCT在重症肺炎患儿中往往呈高表达,与肺功能指标呈负相关,4项指标联合检测对重症肺炎有一定诊断价值。
Objective To investigate the changes of matrix metalloproteinase inhibitor-1(TIMP-1),matrix metalloproteinase 9(MMP-9),interleukin-6(IL-6)and procalcitonin(PCT)in children with severe pneumonia and their relationship with lung function.Methods A total of 80 children with pneumonia admitted to the hospital from January 2019 to January 2022 were divided into severe group(38 cases)and mild group(42 cases)according to the severity of the disease,and 40 healthy children in the same period were selected as the control group.The serum levels of TIMP-1,MMP-9,IL-6 and PCT and lung function indexes of the three groups were compared.Meanwhile,the correlation between serum levels of TIMP-1,MMP-9,IL-6 and PCT and lung function indexes was analyzed.Besides,the diagnostic value of serum TIMP-1,MMP-9,IL-6 and PCT alone and the combined detection in severe pneumonia was analyzed.Results The levels of TIMP-1,MMP-9,IL-6 and PCT in severe group were higher than those in mild group and control group,and those in mild group were higher than those in control group(P<0.05).The levels of PEF,FVC and FEV 1 in severe group were lower than those in mild group and control group,and those in mild group were lower than those in control group(P<0.05).Pearson correlation analysis showed that TIMP-1,MMP-9,IL-6 and PCT were negatively correlated with PEF,FVC and FEV 1 in both severe and mild groups(P<0.05).The AUC of combined detection pf serum TIMP-1,MMP-9,IL-6 and PCT in the diagnosis of severe pneumonia was higher than that of single detection(P<0.05).Conclusion TIMP-1,MMP-9,IL-6 and PCT are highly expressed in children with severe pneumonia,and are negatively correlated with lung function indicators.The combined detection of these four indicators has certain diagnostic value for severe pneumonia.
作者
何明森
何伟
李刚
范志刚
HE Mingsen;HE Wei;LI Gang;FAN Zhigang(Department of Intensive Care Medicine,3201 Hospital,Hanzhong,Shaanxi 723000,China)
出处
《国际检验医学杂志》
CAS
2023年第9期1121-1124,共4页
International Journal of Laboratory Medicine
基金
陕西省重点研发计划项目(2021SF-044)。
