摘要
目的调查生育期、围绝经期和绝经后期女性各年龄段的血脂、脂蛋白水平。方法选取2020年1—12月于浙江中医药大学附属第二医院住院的944例40~60岁女性,根据生殖衰老分期系统STRAW+10标准分为3组:生育期(352例)、围绝经期(127例)、绝经后期(465例)。比较各组患者的BMI和血清TC、TG、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、非高密度脂蛋白胆固醇(non-HDL-C)、载脂蛋白A1(Apo A1)、载脂蛋白B(Apo B)、载脂蛋白E(Apo E)、脂蛋白(a)[Lp(a)]等脂代谢相关指标。结果(1)生育期、围绝经期、绝经后期女性的TC水平分别为(4.65±0.98)mmol/L、(4.75±1.02)mmol/L、(4.99±1.03)mmol/L,差异有统计学意义(P<0.05);3组的TG、LDL-C、non-HDL-C水平差异有统计学意义(均P<0.05);(2)50~60岁3组的TC、LDL-C、non-HDL-C水平差异有统计学意义(均P<0.05);(3)3组的Apo B、Apo E水平差异有统计学意义(均P<0.05);(4)绝经后期TC异常和LDL-C异常的发生率高于生育期、围绝经期(均P<0.017)。结论不同生殖衰老状态女性的部分血脂和脂蛋白发生改变,尤其50岁以上女性血脂水平改变明显。
Objective To analyse the lipid and lipoprotein levels of women in different reproductive aging stages and different age groups.Methods A total of 944 female patients aged from 40 to 60 years who were hospitalized in the Second Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine from January to December 2020 were selected and divided into three groups according to STRAW+10:reproductive period(n=352),perimenopausal period(n=127)and postmenopausal period(n=465).BMI,serum total cholesterol(TC),serum triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),non high-density lipoprotein cholesterol(non-HDL-C),apolipoprotein A1(Apo A1),apolipoprotein B(Apo B),apolipoprotein E(Apo E),and lipoprotein[Lp(a)]were compared in each group.Results(1)The TC level significantly differed among reproductive,perimenopausal and postmenopausal periods[(4.65±0.98)mmol/L vs.(4.75±1.02)mmol/L vs.(4.99±1.03)mmol/L(P<0.05)].The levels of TG,LDL-C and non-HDL-C were also significantly different(all P<0.05).(2)The TC,LDL-C and non-HDL-C levels were significantly different among the three groups with ages ranging from 50 to 60 years(all P<0.05).(3)The levels of Apo B and Apo E were significantly different among the three groups(all P<0.05).(4)The abnormal incidence rates of TC and LDL-C were significantly higher in the postmenopausal period than in the reproductive period or perimenopausal period(all P<0.017).Conclusion Some blood lipids and lipoproteins of women in different reproductive aging states have changed,especially in women aged more than 50 years.
作者
冯钰婷
盛少琴
于晓
FENG Yuting;SHENG Shaoqin;YU Xiao(Nutriology Department,the Second Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou,Zhejiang 310005,China;不详)
出处
《中华全科医学》
2023年第5期784-787,共4页
Chinese Journal of General Practice
基金
浙江省中医药科学研究基金项目(2022ZB155)。
关键词
绝经
血脂
脂蛋白
Menopause
Lipid
Lipoprotein
