摘要
目的通过对轻度认知功能障碍(MCI)患者的睡眠特征进行分析,然后分析MCI与认知功能的关系,为延缓MCI患者的认知功能障碍提供依据。方法选取2019年2月—2022年2月在我院治疗的MCI患者和同期健康体检者各72例作为观察组和对照组。比较2组睡眠和认知功能,分析睡眠特征与认知功能的相关性。结果观察组睡眠障碍发生率(44.44%)明显高于对照组(13.89%,P<0.01);观察组爱泼沃斯睡眠量表(ESS)评分、匹兹堡睡眠质量指数(PSQI)总分以及PSQI量表主观睡眠时间、入睡时间、睡眠时间、睡眠效率、睡眠障碍、日间功能障碍等项目评分均明显高于对照组(均P<0.01);观察组浅睡眠期(S1+S2)%占比明显高于对照组(P<0.01),而深睡眠期(S3+S4)、快速动眼期(REM)睡眠时间、REM睡眠占比明显低于对照组(均P<0.01);观察组蒙特利尔认知功能评估量表(Mo-CA)总分及Mo-CA量表中定向、记忆、视空间和执行功能、命名、语言、注意、抽象概括等项目评分均明显低于对照组(均P<0.01);ESS评分、PSQI总分、PSQI量表中的睡眠质量、入睡时间、睡眠时间、睡眠效率、夜间睡眠障碍、日间功能障碍以及S3+S4(%)、REM睡眠占比与Mo-CA评分呈负相关关系(r=-0.329~-0.213,P=0.001~0.036)。结论MCI患者存在更高比例的睡眠障碍,患者睡眠障碍与认知功能具有显著相关性,患者睡眠质量越差,其深度睡眠期和REM期睡眠越短,认知功能也越差。
Objective To analyze the sleep characteristics of patients with mild cognitive impairment(MCI),and then analyze the relationship between MCI and cognitive function,so as to provide a basis for delaying cognitive dysfunction in MCI patients.Methods A total of 72 MCI patients treated in Hangzhou Seventh People's Hospital from February 2019 to February 2022 and 72 healthy physical examiners in the same period were selected as the observation group and control group,respectively.The sleep and cognitive function were compared between the 2 groups,and the correlation between sleep characteristics and cognitive function was also analyzed.Results The incidence of sleep disorders in the observation group(44.44%)was significantly higher than that in the control group(13.89%,P<0.01).Epworth sleep scale(ESS)scores,Pittsburgh sleep quality index(PSQI)total scores,PSQI subjective sleep time,sleep duration,sleep efficiency,sleep disturbance,daytime dysfunction and other scores were significantly higher in the observation group than in the control group(all P<0.01).The proportion of light sleep(S1+S2)%in the observation group was significantly higher than that in the control group(P<0.01),while deep sleep period(S3+S4),rapid eye movement(REM)sleep and the proportion of REM sleep in the observation group were significantly lower than that in the control group(all P<0.01).The total score of Montreal cognitive function assessment scale(Mo-CA)and scores of orientation,memory,visuospatial and executive function,naming,language,attention,abstract generalization and other items in Mo-CA were significantly lower in observation group than in control group(all P<0.01).ESS score,PSQI total score,PSQI sleep quality,time to fall asleep,sleep duration,sleep efficiency,nighttime sleep disturbance,daytime dysfunction,S3+S4(%)and the proportion of REM sleep in the PSQI scale were significantly negatively correlated with and Mo-CA scores(r was-0.329 to-0.213,P value was 0.001 to 0.036).Conclusion MCI patients have a higher proportion of sleep disorders,and there is a significant correlation between sleep disorders and cognitive function.The worse the sleep quality of patients,the shorter their deep sleep and REM sleep,and the worse their cognitive function.
作者
孙棋圻
高可润
SUN Qiqi;GAO Kerun(Second Department of Psychiatry,Hangzhou Seventh People's Hospital,Affiliated Mental Health Center of Zhejiang University Medical College,Hangzhou,Zhejiang 310013,China)
出处
《中华全科医学》
2023年第5期825-828,共4页
Chinese Journal of General Practice
基金
浙江省医药卫生科技计划项目(2021RC025)。
关键词
轻度认知功能障碍
睡眠障碍
认知功能
相关性
Mild cognitive impairment
Sleep disorders
Cognitive function
Correlation
