摘要
目的 探究乳腺癌患者磁共振成像(MRI)表观弥散系数(ADC值)与病理参数及血清肿瘤标志物关系。方法 选择2019年5月至2022年5月来我院就诊的乳腺癌患者108例作为恶性组,选择同期来我院就诊的乳腺良性病变患者60例作为良性组。收集两组一般资料、血清学指标及影像学数据,比较两组MRI成像的TIC类型、 ADC值以及CA153、CA125、CEA水平,比较不同病理类型乳腺癌ADC值,比较浸润性导管癌(IDC)不同组织学分级ADC值,分析ADC值与CA153、CA125、CEA水平及组织学分级关系,分析ADC值、CA153、CA125及CEA水平对乳腺癌的诊断价值。结果 两组TIC类型比较,差异有统计学意义(P<0.05),恶性组以Ⅲ型为主,良性组以Ⅰ型为主;恶性组的ADC值低于良性组,恶性组的CA153、CA125、 CEA水平均高于对照组(P<0,05);恶性组中,不同病理类型乳腺癌的ADC值比较存在显著差异(P<0.05),IDC的ADC值低于导管原位癌及其他类型(P<0.05);组织学分级不同IDC患者的ADC值比较存在显著差异(P<0.05),Ⅲ级患者的ADC值低于Ⅰ级、Ⅱ级(P<0.05);ADC值与CA153、 CA125、CEA及组织学分级均成负相关(P<0.05);采用ROC曲线分析发现,ADC值与CA153、CA125、CEA联合诊断乳腺癌的AUC为0.986,高于任一单一指标。结论 乳腺癌患者MRI成像ADC值低于乳腺良性病变患者,其与病理参数及血清肿瘤标志物均存在一定关系,临床可将MRI检查与血清肿瘤标志物结合来提高乳腺癌的检出。
Objective The aim of this study was to investigate the relationship between apparent diffusion coefficient(ADC)value in magnetic resonance imaging(MRI)and pathological parameters,serum tumor markers in patients with breast cancer.Methods A total of 108 patients with breast cancer and 60 patients with benign breast lesions treated in the hospital were enrolled as malignant group and benign group between May 2019 and May 2022,respectively.The general data,serological indexes and imaging data in both groups were collected.TIC types,ADC value,CA153,CA125 and CEA levels in the two groups were compared.ADC values in patients with different pathological types of breast cancer and different histological grading of invasive ductal carcinoma(IDC)were compared.The relationship between ADC value and CA153,CA125,CEA levels and histological grading,as well as the diagnostic value of ADC value,CA153,CA125 and CEA levels for breast cancer were analyzed.Results The differences of TIC types in the two groups were statistically significant(P<0.05).The main TIC classifications in malignant group and benign group were type III and type I,respectively.ADC value in malignant group was lower than that in benign group,while CA153,CA125 and CEA levels were higher than those in benign group(P<0.05).In malignant group,there were significant differences in ADC values among patients with different pathological types of breast cancer(P<0.05).ADC value of IDC was lower than that of ductal carcinoma in situ and the other types(P<0.05).There were significant differences in ADC values among IDC patients with different histological grading(P<0.05).ADC value was lower in patients at gradeⅢthan gradeⅠand gradeⅡ(P<0.05).ADC value was negatively correlated with CA153,CA125,CEA and histological grading(P<0.05).ROC curves analysis showed that AUC of ADC combined with CA153,CA125 and CEA in the diagnosis of breast cancer was 0.986,greater than that of single index.Conclusion MRI ADC value in patients with breast cancer is lower than that with benign breast lesions,and there is certain relationship with pathological parameters and serum tumor markers.Clinically,MRI combined with serum tumor markers can improve the detection of breast cancer.
作者
韩龙
张海莲
马琼
HAN long;ZHANG Hai-lian;MA Qiong(Department of Radiology,Affiliated Hospital of Qinghai University,Xining 810001,Qinghai Province,China)
出处
《中国CT和MRI杂志》
2023年第5期76-78,共3页
Chinese Journal of CT and MRI
基金
青海省医药卫生科技项目(2021-wjzdx-80)。
关键词
乳腺癌
磁共振成像
表观弥散系数
病理参数
血清肿瘤标志物
Breast Cancer
Magnetic Resonance Imaging
Apparent Diffusion Coefficient
Pathological Parameter
Serum Tumor Marker
