摘要
人体不同微生态中的各种微生物组成了人体微生物群,包括肠道菌群、口腔菌群等,在人类的代谢、免疫、维持微生态稳态等方面发挥重要的作用。肠道菌群的异常改变即肠道菌群失调,能够导致代谢异常和炎症改变,与包括高血压、糖尿病、炎症性肠病、自身免疫病等疾病状态密切相关。冠状动脉粥样硬化性心脏病(冠心病)病因主要是动脉粥样硬化——一种慢性、进行性炎症性疾病。已经有许多证据表明,肠道菌群与冠心病之间存在相关性。因此,本文拟就肠道菌群构成及其代谢物与冠心病之间的关系展开综述,并探讨可能的研究方向和应用前景。
Including gut microbiota and oral microbiota,various microorganisms in different human ecosystem constitute the human microbiota,which play an important role in human metabolism,immunity and maintaining microecological homeostasis.Abnormal changes in gut microbiota known as dysbiosis may lead to metabolic abnormalities and inflammatory changes,which are closely related to disease states including hypertension,diabetes,inflammatory bowel disease,and autoimmune diseases.The main cause of coronary artery disease is coronary atherosclerosis,a chronic and progressive inflammatory disease.Many evidences have shown that there is a correlation between gut microbiota and coronary artery disease.Therefore,we aim to review the relationship between gut microbiota and coronary artery disease,and discuss the possible research directions and application prospects.
作者
刘恺闻
张魁
周宁
董然
LIU Kaiwen;ZHANG Kui;ZHOU Ning;DONG Ran(Capital Medical University,Beijing,100069,P.R.China;Department of Cardiac Surgery,Beijing Anzhen Hospital Affiliated to Capital Medical University,Beijing,100029,P.R.China)
出处
《中国胸心血管外科临床杂志》
CSCD
北大核心
2023年第5期746-752,共7页
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
基金
国家自然科学基金面上项目(81770412)。
关键词
冠心病
肠道菌群
动脉粥样硬化
氧化三甲胺
综述
Coronary artery disease
gut microbiota
atherosclerosis
trimethylamine N-oxide
review
