摘要
目的探讨胃食管反流病(GERD)患者反流症状评分与血清前列腺素E_(2)(PGE_(2))、胃饥饿素(Ghrelin)及胃泌素(GAS)水平的相关性。方法选择2019年8月至2022年8月陕西航天医院收治的GERD患者150例(GERD组)和同期健康体检者120例(对照组)为研究对象,采用酶联免疫吸附试验检测血清PGE_(2)、Ghrelin和GAS水平。比较GERD组与对照组血清PGE_(2)、Ghrelin、GAS水平和胃食管反流病问卷(GERD-Q)评分,分析不同GERD-Q评分患者血清PGE_(2)、Ghrelin、GAS水平,采用Pearson相关分析GERD患者GERD-Q评分与血清PGE_(2)、Ghrelin、GAS水平的相关性。结果GERD组GERD-Q评分和血清PGE_(2)水平高于对照组,血清Ghrelin、GAS水平低于对照组,差异有统计学意义(P<0.05)。GERD-Q评分为7~10分者血清PGE_(2)水平低于GERD-Q评分为11~14分和15~18分者,血清Ghrelin、GAS水平高于GERD-Q评分为11~14分和15~18分者,差异有统计学意义(P<0.05);GERD-Q评分为11~14分者血清PGE_(2)水平低于GERD-Q评分为15~18分者,血清Ghrelin、GAS水平高于GERD-Q评分为15~18分者,差异有统计学意义(P<0.05)。Pearson相关分析显示,GERD患者GERD-Q评分与血清PGE_(2)水平呈正相关(r=0.510,P<0.05),与血清Ghrelin、GAS水平均呈负相关(r=-0.524、-0.568,P<0.05)。结论血清PGE_(2)、Ghrelin、GAS水平均与GERD患者GERD-Q评分相关,有望成为评估患者反流症状严重程度的血清学标志物。
Objective To investigate the correlations between reflux symptom score and serum prostaglandin E_(2)(PGE_(2)),Ghrelin,gastrin(GAS)levels in patients with gastroesophageal reflux disease(GERD).Methods A total of 150 GERD patients admitted to Shaanxi Aerospace Hospital from August 2019 to August 2022(GERD group)and 120 healthy subjects(control group)were selected as the research objects.Serum levels of PGE_(2),Ghrelin and GAS were detected by enzyme-linked immunosorbent assay.The serum levels of PGE_(2),Ghrelin,GAS and gastroesophageal reflux disease questionnaire(GERD-Q)score were compared between GERD group and control group,and the serum levels of PGE_(2),Ghrelin,GAS in patients with different GERD-Q score were analyzed.Pearson correlation was used to analyze the correlations between GERD-Q score and serum PGE_(2),Ghrelin,GAS levels in GERD patients.Results The GERD-Q score and serum PGE_(2) level in GERD group were higher than those in control group,the serum Ghrelin and GAS levels in GERD group were lower than those in control group,the differences were significant(P<0.05).The serum PGE_(2) level in patients with GERD-Q score of 7-10 was lower than that in patients with GERD-Q score of 11-14 and 15-18,the serum Ghrelin and GAS levels were higher than those in patients with GERD-Q score of 11-14 and 15-18,the differences were significant(P<0.05).Pateints with GERD-Q score of 11-14 had lower serum PGE_(2) level than those of patients with GERD-Q score of 15-18(P<0.05),and had higher serum Ghrelin and GAS levels than those of patients with GERD-Q score of 15-18,the differences were significant(P<0.05).Pearson correlation analysis showed that GERD-Q score in GERD patients correlated positively with serum PGE_(2) level(r=0.510,P<0.05),and negatively correlated with serum Ghrelin and GAS levels(r=-0.524,-0.568,P<0.05).Conclusion Serum levels of PGE_(2),Ghrelin and GAS associate with GERD-Q score in GERD patients,which were expected to be serological markers to evaluate the severity of reflux symptoms in patients.
作者
马睿
乔永刚
MA Rui;QIAO Yonggang(Department of Internal Medicine,Shaanxi Aerospace Hospital,Xi′an,Shaanxi 710025,China;Department of Internal Medicine,Fufeng County Traditional Chinese Medicine Hospital,Baoji,Shaanxi 722299,China)
出处
《检验医学与临床》
CAS
2023年第10期1405-1409,共5页
Laboratory Medicine and Clinic
关键词
胃食管反流病
胃食管反流病问卷
前列腺素E2
胃饥饿素
胃泌素
gastroesophageal reflux disease
gastroesophageal reflux disease questionnaire
prostaglandin E 2
Ghrelin
gastrin
