摘要
目的比较中晚期宫颈癌患者同步放化疗应用容积旋转调强(VMAT)与7野固定野调强放疗(7f-IMRT)的治疗效果。方法选取临沂市肿瘤医院妇科2018-10-04-2019-11-05收治宫颈癌放疗患者40例,按照随机数字表法分为VMAT组22例和7f-IMRT组18例,对比2组计划靶区剂量差异、靶区适形指数(CI)、均匀指数(HI)、投照时间、放疗不良反应和近期有效率。结果VMAT组的CI(0.61±0.11)优于7f-IMRT组(0.55±0.05),P=0.02;VMAT组投照时间为(207.33±11.52)s,短于7f-IMRT组的(406.47±16.62)s,P<0.001;小肠V_(50)(P=0.04)、膀胱V_(50)(P=0.01)、直肠V_(40)(P=0.03)体积在VMAT组均低于7f-IMRT组。2组计划放疗不良反应、靶区剂量,如Dmax、Dmin、Dmean、HI和治疗有效率,差异均无统计学意义,均P>0.05。结论与7f-IMRT比较,VMAT适形度更优,邻近器官受损伤减少,投照时间短,是宫颈癌的理想放疗方案。
Objective To compare the therapeutic effect of volumetric modulated arc therapy(VMAT)and 7-field intensity modulated radiation therapy(7f-IMRT)applied in chemoradiotherapy for patients with middle-and advanced-stage cervical carcinoma.Methods Forty patients with cervical carcinoma receiving radiotherapy at the Department of Gynecology of Linyin Cancer Hospital in the period from October 4,2018 to November 5,2019 were included in the research and divided into the VMAT group(n=22)and the 7f-IMRT group(n=18)using the table of random numbers.The two groups were compared in planning target volume(PTV),target conformal index(CI),homogeneity index(HI),projection time,side effects of radiotherapy,and short-term efficacy.Results The VMAT group showed CI(0.61±0.11)was higher than that of the 7f-IMRT group(0.55±0.05,P=0.02);the VMAT group's projection time[(207.33±11.52)s] was shorter than that of the 7f-IMRT group[(406.47±16.62)s],P<0.001;the small intestine V_(50)(P=0.04),bladder V_(50)(P=0.O1),and rectum V_(40)(P=0.03)volume in the VMAT group were lower than those in the 7f-IMRT group.The difference between the two groups in the exposure dose of organs at risk(OARs)was statistically significant.The differences between the two groups in planning radiotherapy side effects,target volume such as Dmax,Dmin,Dmean,HI,and therapeutic efficiency were not statistically significant,P>0.05.Conclusion Compared with 7f-IMRT,VMAT boasts better conformability,less damage to adjacent organs,and shorter projection time,and is therefore an ideal regime of radiotherapy for treating cervical carcinoma.
作者
丁凤娜
张树茂
刘德梅
李秀敏
王飞华
许萍
李加英
DING Fengna;ZHANG Shumao;LIU Demei;LI Xiumin;WANG Feihua;XU Ping;LI Jiaying(Linyi Tumor Hospital,Linyi276000,China)
出处
《中华肿瘤防治杂志》
CAS
北大核心
2023年第7期424-429,共6页
Chinese Journal of Cancer Prevention and Treatment
基金
临沂市科技发展计划(202020059)。
关键词
容积旋转调强
宫颈癌
固定野调强
疗效
volume rotation intensity modulation
cervical cancer
fixed field intensity modulation
curative effect
