摘要
目的:观察醒脑静注射液辅助急诊溶栓抗凝治疗急性脑梗死(ACI)的临床效果及对死亡率的影响。方法:选取2019年2月—2022年2月内蒙古科技大学包头医学院第一附属医院急诊科收治的112例ACI患者。根据红蓝球法将其分为研究组和对照组,各56例。两组均给予基础治疗。对照组给予急诊溶栓抗凝治疗,研究组在对照组基础上给予醒脑静注射液。比较两组临床疗效,治疗前后血清指标、脑氧代谢、神经功能、生活能力,死亡率和不良反应。结果:两组治疗期间的不良反应发生率比较差异无统计学意义(P>0.05),研究组死亡率低于对照组,差异有统计学意义(P<0.05)。研究组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,研究组同型半胱氨酸(Hcy)、血管紧张素Ⅱ(AngⅡ)水平均低于对照组,差异有统计学意义(P<0.05)。治疗后,研究组动静脉血氧含量差[D(a-jv)O_(2)]、脑氧摄取率(ERO_(2))水平均低于对照组,差异有统计学意义(P<0.05)。治疗后,研究组日常生活能力评定量表(ADL)评分高于对照组,美国国立卫生研究院卒中量表(NIHSS)评分低于对照组,差异有统计学意义(P<0.05)。结论:醒脑静注射液辅助急诊溶栓抗凝治疗可有效改善ACI患者脑氧代谢,降低死亡率,且安全性好,效果确切。
Objective:To observe the clinical effect of Xingnaojing Injection assisted emergency thrombolysis and anticoagulation in the treatment of acute cerebral infarction(ACI)and its effect on mortality.Method:A total of 112 ACI patients admitted to the Emergency Department of the First Affiliated Hospital of Baotou Medical College of Inner Mongolia University of Science and Technology from February 2019 to February 2022 were selected.According to the red and blue ball method,they were divided into the study group and the control group,56 cases in each group.Both groups were given basic treatment.The control group was given emergency thrombolysis and anticoagulant therapy,and the study group was given Xingnaojing Injection on the basis of the control group.The clinical efficacy,serum indexes,cerebral oxygen metabolism,neurological function,living ability before and after treatment,mortality and adverse reactions were compared between the two groups.Result:There was no significant difference in the incidence of adverse reactions between the two groups during the treatment(P>0.05).The mortality rate of the study group was lower than that of the control group,and the difference was statistically significant(P<0.05).The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of homocysteine(Hcy)and angiotensinⅡ(AngⅡ)in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of arteriovenous blood oxygen content difference[D(a-jv)O_(2)]and cerebral oxygen ingestion rate(ERO_(2))in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the daily living ability assessment scale(ADL)score of the study group was higher than that of the control group,and the National Institutes of Health stroke scale(NIHSS)score was lower than that of the control group,and the differences were statistically significant(P<0.05).Conclusion:Xingnaojing Injection assisted emergency thrombolysis and anticoagulation therapy can effectively improve cerebral oxygen metabolism in patients with ACI,reduce mortality,and has good safety and definite effect.
作者
杨叶
YANG Ye(The First Affiliated Hospital of Baotou Medical College of Inner Mongolia University of Science and Technology,Baotou 014010,China)
出处
《中外医学研究》
2023年第13期48-51,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
急性脑梗死
醒脑静注射液
阿替普酶
肝素钠
急诊
Acute cerebral infarction
Xingnaojing Injection
Alteplase
Heparin sodium
Emergency
