摘要
目的:研究旋覆代赭汤联合半夏厚朴汤对胃食管反流病(GERD)患者的效果及对胃动力学相关指标的影响。方法:纳入研究对象共90例,均为佳木斯市中医医院从2019年2月-2021年2月收治的GERD患者,将其按照随机数字表法分成中药组及西药组,各45例。西药组予以常规西药治疗,中药组则于常规西药治疗的基础上增用旋覆代赭汤联合半夏厚朴汤治疗。对比两组临床疗效、治疗前后症状积分及胃动力学相关指标变化情况、不良反应。结果:在总有效率方面对比,中药组相较于西药组更高(P<0.05);治疗后中药组各项症状积分相较于西药组均更低(P<0.05);治疗后中药组胃动素(MTL)水平相较于西药组更高,生长抑素(SS)及血管活性肠肽(VIP)水平相较于西药组均更低(P<0.05);两组头痛、乏力、食欲不振发生率比较,差异均无统计学意义(P>0.05)。结论:旋覆代赭汤联合半夏厚朴汤治疗GERD患者的效果较佳,可有效改善胃动力学相关指标,且不会增加不良反应发生风险,值得推广普及。
Objective:To study the effect of Xuanfu Daizhe Decoction combined with Banxia Houpo Decoction on patients with gastroesophageal reflux disease(GERD)and its influence on gastric motility related indexes.Method:A total of 90 patients with GERD admitted to Jiamusi Hospital of Traditional Chinese Medicine from February 2019 to February 2021 were divided into Chinese medicine group and western medicine group according to the random number table method,with 45 cases in each group.The western medicine group was treated with routine western medicine,and the Chinese medicine group was treated with Xuanfu Daizhe Decoction combined with Banxia Houpo Decoction on the basis of routine western medicine treatment.The clinical efficacy,before and after treatment changes of symptom scores and gastric motility related indexes,adverse reactions were compared between the two groups.Result:Compared with the western medicine group,the total effective rate of Chinese medicine group was higher(P<0.05).After treatment,the symptom scores of the Chinese medicine group were lower than those of the western medicine group(P<0.05).After treatment,the levels of motilin(MTL)in the Chinese medicine group was higher than that in the western medicine group,while the levels of somatostatin(SS)and vasoactive intestinal peptide(VIP)were lower than those in the western medicine group(P<0.05).There were no significant differences in the incidences of headache,fatigue and loss of appetite between the two groups(P>0.05).Conclusion:Xuanfu Daizhe Decoction combined with Banxia Houpo Decoction has a better effect in the treatment of GERD patients,and it can effectively improve gastric motility related indexes,without increasing the risk of adverse reactions,which was worthy of promotion and popularization.
作者
崔嘉
孔媛媛
CUI Jia;KONG Yuanyuan(Jiamusi Hospital of Traditional Chinese Medicine,Heilongjiang Province,Jiamusi 154002,China)
出处
《中国医学创新》
CAS
2023年第13期115-118,共4页
Medical Innovation of China
