摘要
目的:探讨鼻咽癌放疗后患者应用中药超声雾化吸入预防放射性鼻窦炎的效果及对鼻窦功能、机体炎症反应的影响。方法:选取2018年8月—2020年12月长葛市人民医院收治的95例鼻咽癌放疗后患者作为研究对象,采用随机抽签法分为对照组47例和观察组48例。对照组给予鼻腔冲洗,观察组在鼻腔冲洗基础上给予中药超声雾化鼻吸入。对比两组患者放射性鼻窦炎发生率、临床症状改善情况、鼻窦功能[慢性鼻窦炎鼻息肉患者内镜评分系统(Lund-kennedy)评分、纤毛传输速率]、机体炎症反应水平[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)]。结果:观察组放射性鼻窦炎发生率低于对照组,差异有统计学意义(χ2=5.2065,P=0.0225)。干预后,观察组患者头痛、鼻塞、流涕、嗅觉功能减退评分均低于对照组,差异有统计学意义(t=5.8944、5.3508、4.9837、5.9317,P<0.05)。干预后,观察组纤毛传输速率高于对照组,Lund-kennedy评分低于对照组,差异有统计学意义(t=7.1424、7.8281,P<0.05)。干预后,观察组患者hs-CRP、TNF-α水平均低于对照组,差异有统计学意义(t=7.4100、7.0275,P<0.05)。结论:中药超声雾化吸入联合鼻腔冲洗能够减轻鼻咽癌放疗后患者临床症状,降低放射性鼻窦炎发生率,减轻炎症反应,改善鼻窦功能。
Objective:To investigate the effect of traditional Chinese medicine ultrasound atomization on the prevention of ra⁃dioactive sinusitis in patients with nasopharyngeal carcinoma after radiotherapy,and the effect on the function of nasal sinus and the inflammatory response of the body.Methods:95 patients admitted to the hospital after radiotherapy for nasopharyngeal carcino⁃ma from August 2018 to December 2020 were selected as study subjects,and were divided into 47 cases in the control group and 48 cases in the observation group using the random lottery method.The control group was given nasal irrigation,and the observa⁃tion group was given ultrasonic nebulized nasal inhalation of traditional Chinese medicine on the basis of the control group.The in⁃cidence of radiation sinusitis,improvement of clinical symptoms,sinus function(endoscopic scoring system[Lund-kennedy]score,cilia transmission rate in patients with chronic sinusitis and nasal polyps),and the level of organismal inflammatory response(hyper⁃sensitive C-reactive protein[hs-CRP],tumor necrosis factor-α[TNF-α])were compared between the two groups.Results:The in⁃cidence of radiation sinusitis in the observation group was lower than that in the control group,and the difference was statistically significant(χ2=5.2065,P=0.0225).After the intervention,the scores of headache,nasal congestion,runny nose,and reduced olfac⁃tory function were lower in the observation group than in the control group,with statistically significant differences(t=5.8944,5.3508,4.9837,5.9317,P<0.05).After the intervention,the cilia transmission rate was higher in the observation group than in the control group,and the Lund-kennedy score was lower than in the control group,with statistically significant differences(t=7.1424,7.8281,P<0.05).After the intervention,the hs-CRP and TNF-αlevels of patients in the observation group were lower than those in the control group,and the difference was statistically significant(t=7.4100,7.0275,P<0.05).Conclusion:Ultrason⁃ic nebulized inhalation of Chinese medicine combined with nasal rinsing can reduce clinical symptoms,decrease the incidence of radiation sinusitis,reduce the inflammatory response and improve sinus function in patients after radiotherapy for nasopharyngeal cancer.
作者
李菲
LI Fei(Changge People’s Hospital,Xuchang,Henan,461500,China)
出处
《黑龙江医学》
2023年第11期1386-1388,共3页
Heilongjiang Medical Journal
关键词
鼻咽癌
中药超声雾化
放射性鼻窦炎
炎症反应
鼻窦功能
Nasopharyngeal carcinoma
Ultrasonic atomization of traditional Chinese medicine
Radioactive sinusitis
Inflamma⁃tory response
Sinus function
