摘要
前列腺癌(Pca)是一种类固醇激素依赖的癌症,早期临床表现相对隐匿,不易诊断,中晚期常伴远处转移,预后极差。目前,临床上仍缺乏特异性的肿瘤标志物,难以有效地监测肿瘤的发生发展、耐药、诊断及有效的预后评估,致使临床治疗效果不佳。大量研究表明,长链非编码RNA(LncRNA)作为关键的调节因子,在Pca的发生发展、耐药和预后评估等方面发挥着重要的作用。因此,深入探讨LncRNA在Pca中的作用及其临床应用是十分有必要的,为Pca的诊断及其靶向治疗提供新的视角。
Prostate cancer(Pca)is a kind of steroid hormone-dependent cancer.Its early clinical manifestations are relatively insidious,and difficult to diagnose.It is often accompanied by distant metastasis in the middle and late stages,and its prognosis is very poor.At present,there is still a lack of specific tumor markers in clinic,and it is difficult to effectively monitor the occurrence,development,drug resistance,diagnosis and effective prognosis assessment of tumors,resulting in poor clinical treatment effect.A large number of studies have shown that long non-coding RNA(LncRNA),as a key regulatory factor,plays an important role in the occurrence and development of Pca,drug resistance and prognosis assessment.Therefore,it is necessary to thoroughly explore the role of LncRNA in Pca and its clinical application,and provide a new perspective for Pca diagnosis and targeted therapy.
作者
郑江婷
寸淑娥(综述)
王玉明(审校)
ZHENG Jiangting;CUN Shue;WANG Yuming(Clinical Laboratory,The Second Affiliated Hospital of Kunming Medical University,Kunming,Yunnan 650101,China)
出处
《现代医药卫生》
2023年第11期1910-1916,共7页
Journal of Modern Medicine & Health
基金
云南省科技人才和平台计划(院士专家工作站)(2019IC034)
昆明医科大学第二附属医院内科技计划资助项目(2020yk004)。
