摘要
目的探究黄葵敛肠汤加减联合糖皮质激素治疗炎症性肠病(inflammatory bowel disease,IBD)的疗效及对患者肠道菌群的影响。方法选取2018年1月-2021年12月该院就诊的106例IBD患者,随机数字表法将其设为研究组与对照组各53例。对照组接受糖皮质激素治疗,研究组在此基础上联用黄葵敛肠汤加减治疗。比较两组疗效、中医证候积分、肠道菌群、炎症指标及免疫指标变化情况。结果研究组治疗总有效率92.45%(49/53),比对照组75.47%(40/53)高(P<0.05);研究组治疗后中医证候积分、大肠杆菌均比对照组低,乳杆菌、双歧杆菌均比对照组高(P<0.05);研究组治疗后白细胞介素6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)均比对照组低(P<0.05);研究组治疗后免疫球蛋白M(IgM)、免疫球蛋白G(IgG)、免疫球蛋白A(IgA)均比对照组低(P<0.05)。结论黄葵敛肠汤加减联合糖皮质激素治疗炎症性肠病疗效确切,抑炎作用显著,可有效改善患者肠道菌群。
Objective To explore the curative effect of Modified Huangkui Lianchang Decoction(黄葵敛肠汤)combined with glucocorticoids in the treatment of inflammatory bowel disease(IBD)and the influence on intestinal flora.Methods A total of 106 patients with IBD treated in the hospital from January 2018 to December 2021 were selected.They were divided into study group and control group by random number table method,with 53 cases in each group.Patients in the control group were treated with glucocorticoids,and those in the study group were treated with Modified Huangkui Lianchang Decoction on this basis.The curative effect,TCM syndrome scores,intestinal flora,inflammatory indicators and immune indicators were compared between the two groups.Results The total treatment response rate in the study group(92.45%,49/53)was higher than that in the control group(75.47%,40/53)(P<0.05).After treatment,TCM syndrome scores and the level of Escherichia coli in the study group were lower than those in the control group,while the levels of Lactobacillus and Bifidobacterium were higher than those in the control group(P<0.05).After treatment,the levels of interleukin-6(IL-6),C-reactive protein(CRP)and tumor necrosis factorα(TNF-α)in the study group were lower than those in the control group(P<0.05).The levels of immunoglobulin M(IgM),immunoglobulin G(IgG)and immunoglobulin A(IgA)in the study group were lower than those in the control group(P<0.05).Conclusion Huangkui Lianchang Decoction combined with glucocorticoids is effective in the treatment of IBD,with significant anti-inflammatory effect.In addition,the combined treatment can effectively improve intestinal flora in the patients.
作者
何小姣
魏晓广
王权
奚再兴
HE Xiaojiao;WEI Xiaoguang;WANG Quan;XI Zaixing(Nanyang First People′s Hospital,Nanyang 473000,Henan,China)
出处
《辽宁中医杂志》
CAS
2023年第5期90-93,共4页
Liaoning Journal of Traditional Chinese Medicine
关键词
炎症性肠病
中药疗法
糖皮质激素
临床疗效
肠道菌群
inflammatory bowel disease
traditional Chinese medicine therapy
glucocorticoid
clinical effect
intestinal flora
