摘要
目的 分析银杏二萜内酯葡胺联合阿加曲班在急性脑梗死中的应用效果。方法 选取2021年5月至2022年5月河南省直第三人民医院收治的74例急性脑梗死患者,按随机数字表法分为研究组与对照组,各37例。对照组接受阿加曲班治疗,研究组在对照组基础上加用银杏二萜内酯葡胺。对比两组疗效、美国国立卫生院卒中量表(NIHSS)评分、日常生活能力量表(ADL)评分、泛素羧基末端水解酶L1(UCH-L1)水平、血小板活化因子(PAF)水平、膀胱抑素C(CysC)水平、血流流变学(全血黏度、血细胞比容)、炎症因子水平[肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)]、中风病患者生存质量量表(QOLISP)评分。结果 研究组总有效率[91.89%(34/37)]较对照组[72.97%(27/37)]高(P<0.05)。治疗后,研究组NIHSS评分较对照组低,ADL评分较对照组高(P<0.05)。治疗后,研究组血清UCH-L1、PAF、CysC水平、全血黏度、血细胞比容、血清TNF-α、hs-CRP较对照组低,研究组QOLISP评分较对照组高(P<0.05)。结论 银杏二萜内酯葡胺联合阿加曲班治疗急性脑梗死患者,可下调UCH-L1、PAF、CysC水平,减轻炎症刺激,改善血液流变学指标,并能减轻神经功能缺损,提高日常生活能力和生活质量,临床效果显著。
Objective To analyze the application effect of ginkgo biloba diterpene lactone glumine combined with agattriban on acute cerebral infarction.Methods Seventy-four patients with acute cerebral infarction in the Third People’s Hospital of Henan Province from May 2021 to May 2022 were selected and divided into study group and control group according to random number table method,37 cases in each group.The control group received agatriban,and the study group received ginkgo diterpene lactone glumine on the basis of control group.Efficacy,National Institutes of Health stroke scale(NIHSS),ability of daily living scale(ADL),ubiquitin carboxy-terminal hydrolase L1(UCH-L1)level,platelet activating factor(PAF)level,cystatin C(CysC)level,blood flow rheology(whole blood viscosity,hematopoietic volume),and inflammatory factors levels[Tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP)],quality of life in stroke patient scale(QOLISP)score of the two groups were compared.Results The total effective rate of the study group[91.89%(34/37)]was higher than that of the control group[72.97%(27/37)](P<0.05).After treatment,the NIHSS score of the study group was lower than that of the control group,and the ADL score was higher(P<0.05).After treatment,serum UCH-L1,PAF and CysC levels,whole blood viscosity and hematocrit,serum TNF-αand hs-CRP in the study group were lower than those in the control group,and the QOLISP score of the study group was higher than that of the control group(P<0.05).Conclusion Ginkgo diterpene lactone glumine combined with agattriban in the treatment of acute cerebral infarction can reduce UCH-L1,PAF and CysC levels,reduce inflammatory stimuli,improve hemorheology indexes,reduce neurological deficits,improve daily living ability and quality of life,with significant clinical effects.
作者
朱珊珊
崔丽
徐军伟
ZHU Shanshan;CUI Li;XU Junwei(Department of Pharmacy,the Third People’s Hospital of Henan Province,Zhengzhou 450000,China)
出处
《河南医学研究》
CAS
2023年第11期2043-2047,共5页
Henan Medical Research
关键词
急性脑梗死
银杏二萜内酯葡胺
阿加曲班
acute cerebral infarction
ginkgo diterpene lactone glumine
agatuban
