摘要
目的 探讨葛根素静脉滴注对脑出血后脑血管痉挛的治疗效果及一氧化氮(NO)、内皮素-1(ET-1)水平的影响。方法 选取2020年6月至2022年6月大庆龙南医院收治的80例脑出血后脑血管痉挛患者作为研究对象,按随机数字表法分为葛根素组与常规组,每组40例。常规组采取常规对症治疗,葛根素组在常规组基础上增加葛根素静脉滴注。比较两组患者临床治疗效果,治疗前后一氧化氮(NO)、内皮素-1(ET-1)、肿瘤坏死因子-α(TNF-α)、降钙素原(PCT)、超敏C反应蛋白(hs-CRP)水平,日常生活能力与生命质量。结果 葛根素组治疗有效率为92.50%,稍高于常规组(87.50%),但两组差异无统计学意义(P>0.05);治疗后,两组患者NO水平升高,葛根素组高于常规组,ET-1水平降低,葛根素组更低,差异有统计学意义(P<0.05);治疗后,两组患者TNF-α、PCT、hs-CRP水平降低,且葛根素组低于常规组,差异有统计学意义(P<0.05);治疗后3个月和6个月,两组患者日常生活活动能力(ADL)与生命质量评分升高,且葛根素组高于常规组,差异有统计学意义(P<0.05)。结论 对脑出血后脑血管痉挛患者在常规治疗基础上采取葛根素静脉滴注能够提升临床疗效,改善血管内皮功能,减轻机体炎症反应,进一步提升患者远期生命质量和日常生活能力。
Objective To explore the effect of puerarin intravenous infusion on cerebral vasospasm after cerebral hemorrhage and its effect on the levels of nitric oxide(NO)and endothelin-1(ET-1).Methods Eighty patients with cerebral vasospasm after intracerebral hemorrhage admitted to Daqing Longnan Hospital from June 2020 to June 2022 were selected as the research objects,and were divided into puerarin group and conventional group according to random number table,with 40 cases in each group.Patients in the conventional group received routine symptomatic treatment,while the puerarin group received intravenous infusion of puerarin in addition to the conventional group.The clinical treatment effect,nitric oxide(NO),endothelin 1(ET-1),tumor necrosis factor-α(TNF-a),proneneneba calcitonin(PCT),high-sensitivity C-reactive protein(hs-CRP)before and after treatment,ability of daily living and quality of life of the two groups were compared.Results The effective rate of treatment in the puerarin group was 92.50%,slightly higher than that in the conventional group(87.50%),but there was no statistically significant difference between the two groups(P>0.05);After treatment,the NO levels of the two groups of patients increased,with the puerarin group being higher than the conventional group,and the levels of ET-1 in the two groups of patients decreased,while those in the puerarin group were lower,with a statistically significant difference(P<0.05);After treatment,The levels of TNF-α、PCT and hs-CRP were decreased in the two groups,and the puerarin group was lower than the conventional group,with a statistically significant difference(P<0.05);Afer 3 and 6 months of treatment,the ADL and quality of life scores of the two groups of patients increased,and the puerarin group was higher than the conventional group,with a statistically significant difference(P<0.05).Conclusion Taking puerarin intravenous drip on the basis of routine treatment for patients with cerebral vasospasm after intracerebral hemorrhage can improve their clinical efficacy,improve vascular endothelial function,reduce the inflammatory reaction of patients,and further improve the long-term quality of life and ability of daily life of patients.
作者
李显伟
LI Xian-Wei(Department of Neurosurgery,Daqing Longnan Hospital,DaQing 163454,China)
出处
《中国药物经济学》
2023年第5期93-96,101,共5页
China Journal of Pharmaceutical Economics
关键词
葛根素
静脉滴注
脑出血
脑血管痉挛
一氧化氮
内皮素-1
生命质量
Puerarin
Intravenous infusion
Cerebral hemorrhage
Cerebral vasospasm
Nitric oxide
Endothelin-1
Quality of life
