摘要
目的:探讨肝区深部热疗对中晚期肝细胞癌(hepatocellular carcinoma,HCC)肝动脉化疗栓塞术(transcatheter arterial chemoembolization,TACE)后患者甲胎蛋白(alpha-fetoprotein,AFP)及不良反应的影响。方法:选取2020年1月—2021年12月广西医科大学附属武鸣医院肿瘤科住院的120例中晚期HCC TACE后患者为研究对象。随机将其分为对照组及试验组,各60例。对照组TACE后采用常规处理方法,试验组TACE后在对照组基础上给予肝区深部热疗。比较两组TACE后3 d、7 d、14 d、21 d的AFP水平及不良反应。结果:TACE后3 d、7 d、14 d、21 d,两组AFP水平持续下降,差异有统计学意义(P<0.05);试验组TACE后7 d、14 d、21 d的AFP水平均低于对照组,差异有统计学意义(P<0.05)。两组血液系统损害比较,差异无统计学意义(P>0.05);试验组肝区疼痛、消化系统反应、肝功能损害发生率均低于对照组,差异有统计学意义(P<0.05)。结论:中晚期HCC TACE后患者采取肝区深部热疗,可显著降低血清AFP水平,减少术后常见不良反应。
Objective:To investigate the effect of deep hepatic hyperthermia on alpha-fetoprotein(AFP)and adverse reactions in patients with middle and late stage hepatocellular carcinoma(HCC)after transcatheter arterial chemoembolization(TACE).Method:A total of 120 patients with middle and late stage HCC after TACE admitted to the Department of Oncology of Wuming Hospital of Guangxi Medical University from January 2020 to December 2021 were selected as the study objects.They were randomly divided into control group and experimental group,60 cases in each group.The control group received conventional treatment method after TACE,and the experimental group received deep hepatic hyperthermia after TACE on the basis of the control group.AFP levels at 3 d,7 d,14 d and 21 d after TACE and adverse reactions were compared between the two groups.Result:At 3 d,7 d,14 d and 21 d after TACE,AFP levels continued to decrease,and the difference was statistically significant(P<0.05).AFP levels in experimental groups were lower than those in control group at 7 d,14 d and 21 d after TACE,and the differences were statistically significant(P<0.05).There was no significant difference in blood system damage between the two groups(P>0.05).The incidences of liver area pain,digestive system reaction and liver function damage in experimental group were lower than those in control group,the differences were statistically signficant(P<0.05).Conclusion:Taking deep hepatic hyperthermia can significantly reduce serum AFP level and reduce common postoperative adverse reactions for patients with middle and late stage HCC after TACE.
作者
聂荣军
林国享
张珍妮
梁海莹
李书有
NIE Rongjun;LIN Guoxiang;ZHANG Zhenni;LIANG Haiying;LI Shuyou(Wuming Hospital of Guangxi Medical University,Nanning 530199,China;不详)
出处
《中外医学研究》
2023年第17期127-130,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
广西自然科学基金项目(2020GXNSFAA297109)
南宁市武鸣区科学研究与技术开发计划项目(20190405)
广西壮族自治区卫健委自筹科研课题项目(Z20190748,Z20200424)。
关键词
肝区深部热疗
中晚期
肝细胞癌
肝动脉化疗栓塞术
甲胎蛋白
Deep hepatic hyperthermia
Middle and late stage
Hepatocellular carcinoma
Transcatheter arterial chemoembolization
Alpha-fetoprotein
