摘要
目的 本文的研究目的是中晚期原发性肝癌介入治疗的临床效果及对肝功能的影响。方法 选取河南省肿瘤医院介入科收治的中晚期原发性肝癌患者98例作为此次研究的对象,纳入时间段为2021年9月24日—2022年9月24日,将其分成普通组和介入组,每组各有患者49例,其中普通组患者采取碘化油介入治疗,介入组采取载药微球介入治疗,最后分别对比两组患者的临床效果、肝功能水平、生活质量、不良反应发生率、2年生存率及总生存期。结果 介入组总有效率(87.76%)高于普通组的63.27%,P<0.05;两组治疗前ALT、TBIL及ALB比较无统计学意义(P>0.05),治疗后,两组患者的ALB均升高,TBIL、ALT均降低,且介入组患者的ALB(41.70±4.01)g/L,明显高于普通组,介入组TBIL(35.75±4.97)μmol/L、ALT(52.63±6.07)U/L,均低于普通组,数据差异有统计学意义,P<0.05;两组治疗前QOL评分比较无统计学意义(P>0.05),介入组治疗后QOL评分(41.67±2.89)分,高于普通组的(32.78±1.78)分,差异具有统计学意义,P<0.05;介入组不良反应发生率12.24%,低于普通组的28.57%(P<0.05);介入组患者的2年生存率高于普通组,OS也比普通组的更长,数据差异具有统计学意义,P<0.05。结论 中晚期原发性肝癌采取介入治疗的方式,能够明显提升疗效,提高患者肝功能水平,改善其肝功能,提升生活质量以及降低不良反应。
Objective To study the clinical effect of interventional therapy for advanced primary liver cancer and the in⁃fluence on liver function.Methods A total of 98 patients with advanced primary liver cancer admitted to the Interven⁃tional Department of our hospital were selected as the objects of this study.The inclusion period was from September 24,2021 to September 24,2022,and they were divided into two groups.Normal group and intervention group,each group had 49 cases patients,which took iodized oil interventional therapy in patients with normal group,intervention group of took carrier drug microsphere interventional treatment,finally,respectively,the clinical effect,liver function level and quality of life,the incidence of adverse reactions,2 years survival and overall survival of two groups of patients were compared.Results The total effective rate of intervention group was 87.76%,higher than that of ordinary group(63.27%),P<0.05.The comparison of ALT,TBIL and ALB between the two groups before treatment was not satisti⁃cally significant,P>0.05.After treatment,the ALB of the two groups was increased,while the TBIL and ALT were de⁃creased,and the ALB of the intervention group(41.70±4.01)g/L was significantly higher than that of the ordinary group.TBIL(35.75±4.97)μmol/L and ALT(52.63±6.07)U/L were lower than those of normal group,and the difference was statistically significant(P<0.05).QOL score of the two groups before treatment was not statistically sig⁃nificant(P>0.05),QOL score of the interventional group after treatment was(41.67±2.89)points,higher than that of the ordinary group(32.78±1.78)points,the difference was statistically significant(P<0.05).The incidence of adverse reactions in intervention group was 12.24%,which was lower than that of ordinary group(28.57%),P<0.05.The 2-year survival rate of patients in the intervention group was higher than that of the common group,and the OS was also longer than that of the common group.The data difference had statistical significance(P<0.05).Conclusion Interventional therapy for advanced primary liver cancer can significantly improve the efficacy,improve the level of liver function,improve the liver function,improve the quality of life,reduce the incidence of adverse reactions.
作者
朱艳
王梦博
袁航
陈珂
ZHU Yan;WANG Meng-bo;YUAN Hang;CHEN Ke(Minimally invasive intervention ward 2,Henan Cancer Hospital,Affiliated Cancer Hospital of Zhengzhou University,Zhengzhou 450000,China)
出处
《医药论坛杂志》
2023年第9期21-24,共4页
Journal of Medical Forum
关键词
中晚期原发性肝癌
介入治疗
碘化油
载药微球
肝功能
Advanced primary liver cancer
Interventional therapy
Iodized oil
Drug-loaded microspheres
Liver function
