摘要
Hair follicle stem cells(HFSCs)reside in the bulge region of the outer root sheath of the hair follicle.They are considered slow-cycling cells that are endowed with multilineage differentiation potential and superior proliferative capacity.The normal morphology and periodic growth of HFSCs play a significant role in normal skin functions,wound repair and skin regeneration.The HFSCs involved in these pathophysiological processes are regulated by a series of cell signal transduction pathways,such as lymphoid enhancer factor/T-cell factor,Wnt/β-catenin,transforming growth factor-β/bone morphogenetic protein,Notch and Hedgehog.The mechanisms of the interactions among these signaling pathways and their regulatory effects on HFSCs have been previously studied,but many mechanisms are still unclear.This article reviews the regulation of hair follicles,HFSCs and related signaling pathways,with the aims of summarizing previous research results,revealing the regulatory mechanisms of HFSC proliferation and differentiation and providing important references and new ideas for treating clinical diseases.
基金
supported by the National Natural Science Foundation of China(81772136,82172205,81902042)
the Medical Scientific Research Foundation of Guangdong Province(A2018113)
the Guangdong Basic and Applied Basic Research Foundation(2021A1515011453,2022A1515012160)
the Special Fund of Foshan Summit plan(2019C002,2019D008,2019A006 and 2020A015)
the Foundation of Foshan City(FS0AA-KJ218-1301-0034,2018AB003411).
