摘要
目的 探讨解郁化痰饮对冠心病经皮冠状动脉介入术(Percutaneous coronary intervention, PCI)后伴发焦虑抑郁患者的治疗作用。方法 选择解放军总医院第四医学中心2020年9月至2021年6月收治的60例冠心病PCI术后伴发焦虑抑郁患者,采用随机数字表法分为对照组与试验组,各30例。两组PCI术后均给予冠心病二级预防用药,在此基础上,对照组给予氟哌噻吨美利曲辛片联合度洛西汀治疗,试验组给予解郁化痰饮治疗,共治疗4周。对两组临床疗效、治疗前后心境状态[焦虑(Hamilton anxiety scale, HAMA)、抑郁(Hamilton depression scale, HAMD)]评分、中医证候积分、生存质量(The world health organization quality of life, WHOQOL-BREF)评分进行比较。结果 (1)临床疗效:试验组临床疗效总有效率高于对照组(P<0.05)。(2)心境状态:治疗后两组HAMA、HAMD评分均较治疗前降低,且试验组低于对照组(P<0.05)。(3)中医证候积分:治疗后两组中医证候主症、次症各项积分均较治疗前降低,且试验组低于对照组(P<0.05)。(4)生存质量:治疗后两组WHOQOL-BREF各维度评分均较治疗前增加,且试验组高于对照组(P<0.05)。(5)不良反应发生率:治疗期间,两组肝肾功能、血常规、尿常规及各项生命体征均未出现异常,对照组不良反应发生率高于试验组(P<0.05)。结论 解郁化痰饮可有效缓解冠心病PCI术后患者焦虑抑郁情绪,有利于改善生存质量,治疗效果显著,且安全性高。
Objective To explore the therapeutic effect of Jieyu Huatan decoction on patients with anxiety and depression after percutaneous coronary intervention(PCI)of coronary heart disease.Methods 60 patients with anxiety and depression after PCI treated in the hospital from September 2020 to June 2021 were selected and divided into control group and experimental group by random number table method,with 30 cases in each group.Both groups were given secondary prevention drugs for coronary heart disease after PCI,on this basis,the control group was treated with flupentixiol melitracen tablets combined with duloxetine;the experimental group was treated with Jieyu Huatan decoction,the treatment lasted for 4 weeks.The two groups were compared in clinical efficacy,anxiety scale(HAMA),depression scale(HAMD)scores,TCM syndrome scores and the world health organization′s quality of life questionnaire(WHOQOL-BREF)scores before and after the treatment.Results(1)Clinical efficacy:The total effective rate of experimental group was higher than that of control group(P<0.05).(2)Mood state:After the treatment,HAMA and HAMD scores of the two groups were lower than those before the treatment,and the experimental group was lower than control group(P<0.05).(3)TCM syndrome score:After the treatment,the scores of the main symptoms and secondary symptoms of the two groups were lower than before the treatment,and the scores of the experimental group were lower than that of control group(P<0.05).(4)Quality of life:After the treatment,the scores of each dimension of WHOQOL-BREF in the two groups were increased compared with those before the treatment,and the scores in the experimental group were higher than those in control group(P<0.05).(5)Incidence of adverse reactions:During the treatment,there was no abnormality in liver and kidney function,blood routine test,urine routine test and various vital signs in the two groups.The incidence of adverse reactions in control group was higher than that in experimental group(P<0.05).Conclusion Jieyu Huatan decoction can effectively relieve the anxiety and depression of the patients with coronary heart disease after PCI,and is conducive to improve the quality of life,with significant therapeutic effect and high safety.
作者
左昭
侯乃靖
王晶
ZUO Zhao;HOU Naijing;WANG Jing(The Fourth Medical Center of the PLA General Hospital,Beijing 100142,China;The Second Medical Center of the PLA General Hospital,Beijing 100853,China)
出处
《新疆医科大学学报》
CAS
2023年第6期837-842,共6页
Journal of Xinjiang Medical University
基金
北京市创新培育基金项目(HLCX202109)。
关键词
冠心病
PCI术
焦虑抑郁
解郁化痰饮
心境状态
生存质量
coronary heart disease
percutaneous coronary intervention
anxiety and depression
Jieyu Huatan decoction
emotional state
quality of life
